slc25a12.L solute carrier family 25 member 12 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: slc25a12.L
Official Full Name: solute carrier family 25 member 12 L homeolog
Primary source: Xenbase:XB-GENE-1002106
Locus tag: XELAEV_18044692mg
See related: EnsemblRapid:ENSXLAG00005030192 AllianceGenome:Xenbase:XB-GENE-1002106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: slc25a12
Summary: Predicted to enable L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and calcium ion binding activity. Predicted to act upstream of or within L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (76003448..76112179, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (65487732..65597354, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables L-aspartate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-glutamate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within malate-aspartate shuttle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 25 member 12 L homeolog

Names: solute carrier family 25 (aspartate/glutamate carrier), member 12 L homeolog; solute carrier family 25 (mitochondrial carrier, Aralar), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091799.1 → NP_001085268.1 solute carrier family 25 member 12 L homeolog

See identical proteins and their annotated locations for NP_001085268.1

Status: PROVISIONAL

Source sequence(s)

BC094139

UniProtKB/TrEMBL

A0A974BZ77, Q52KY7, Q6INL0

Related

ENSXLAP00005090747.1, ENSXLAT00005092427.1

Conserved Domains (4) summary

PTZ00168
Location:324 → 585

PTZ00168; mitochondrial carrier protein; Provisional

pfam00153
Location:326 → 417

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:14 → 78

EF-hand_7; EF-hand domain pair

cl08302
Location:16 → 78

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

76003448..76112179 complement

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GenBank, FASTA, Sequence Viewer (Graphics)