sae1.L SUMO1 activating enzyme subunit 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sae1.L
Official Full Name: SUMO1 activating enzyme subunit 1 L homeolog
Primary source: Xenbase:XB-GENE-923367
Locus tag: XELAEV_18039273mg
See related: EnsemblRapid:ENSXLAG00005028970 AllianceGenome:Xenbase:XB-GENE-923367
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: aos; sae1; Aos1p; Sua1p; uble1a
Summary: Predicted to enable ubiquitin-like modifier activating enzyme activity. Predicted to contribute to SUMO activating enzyme activity. Predicted to act upstream of or within protein sumoylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SUMO activating enzyme complex. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (68751680..68782410, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (55252790..55283647, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables SUMO activating enzyme activity	IEA Inferred from Electronic Annotation more info
contributes_to SUMO activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein sumoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SUMO activating enzyme complex	IEA Inferred from Electronic Annotation more info
part_of SUMO activating enzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SUMO-activating enzyme subunit 1

Names: SUMO-1 activating enzyme E1 N subunit; SUMO-activating enzyme E1 N subunit; ubiquitin-like 1-activating enzyme E1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091789.1 → NP_001085258.1 SUMO-activating enzyme subunit 1

See identical proteins and their annotated locations for NP_001085258.1

Status: PROVISIONAL

Source sequence(s)

BC086263

UniProtKB/Swiss-Prot

Q8JGT5

UniProtKB/TrEMBL

A0A974C7P9

Related

ENSXLAP00005086428.1, ENSXLAT00005088090.1

Conserved Domains (2) summary

cd01492
Location:14 → 339

Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam00899
Location:17 → 165

ThiF; ThiF family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

68751680..68782410 complement

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GenBank, FASTA, Sequence Viewer (Graphics)