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sae1.L SUMO1 activating enzyme subunit 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 443558, updated on 4-Nov-2024

Summary

Official Symbol
sae1.L
Official Full Name
SUMO1 activating enzyme subunit 1 L homeolog
Primary source
Xenbase:XB-GENE-923367
Locus tag
XELAEV_18039273mg
See related
EnsemblRapid:ENSXLAG00005028970 AllianceGenome:Xenbase:XB-GENE-923367
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
aos; sae1; Aos1p; Sua1p; uble1a
Summary
Predicted to enable ubiquitin-like modifier activating enzyme activity. Predicted to contribute to SUMO activating enzyme activity. Predicted to act upstream of or within protein sumoylation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SUMO activating enzyme complex. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See sae1.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (68751680..68782410, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (55252790..55283647, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 9 L homeolog Neighboring gene uncharacterized XB22065716 L homeolog Neighboring gene zinc finger CCCH-type containing 4 L homeolog Neighboring gene provisional ortholog of CDC42 effector protein 2 L homeolog

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC78909

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables SUMO activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to SUMO activating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein modification by small protein conjugation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein modification process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IEA
Inferred from Electronic Annotation
more info
 
part_of SUMO activating enzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SUMO-activating enzyme subunit 1
Names
SUMO-1 activating enzyme E1 N subunit
SUMO-activating enzyme E1 N subunit
ubiquitin-like 1-activating enzyme E1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091789.1NP_001085258.1  SUMO-activating enzyme subunit 1

    See identical proteins and their annotated locations for NP_001085258.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086263
    UniProtKB/Swiss-Prot
    Q8JGT5
    UniProtKB/TrEMBL
    A0A974C7P9
    Related
    ENSXLAP00005086428.1, ENSXLAT00005088090.1
    Conserved Domains (2) summary
    cd01492
    Location:14339
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:17165
    ThiF; ThiF family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    68751680..68782410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018228860.2XP_018084349.1  SUMO-activating enzyme subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J0TEN4