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TNF tumor necrosis factor [ Ovis aries (sheep) ]

Gene ID: 443540, updated on 5-Mar-2024

Summary

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Gene symbol
TNF
Gene description
tumor necrosis factor
See related
EnsemblRapid:ENSOARG00020016121
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
TNF-alpha
Orthologs
human mouse all
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Genomic context

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See TNF in Genome Data Viewer
Location:
chromosome: 20
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 20 NC_056073.1 (26798126..26800865, complement)

Chromosome 20 - NC_056073.1Genomic Context describing neighboring genes Neighboring gene allograft inflammatory factor 1 Neighboring gene leukocyte specific transcript 1 Neighboring gene uncharacterized LOC114109638 Neighboring gene lymphotoxin beta Neighboring gene lymphotoxin alpha Neighboring gene NFKB inhibitor like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056073.1 Chromosome 20 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Primary structure of ovine tumor necrosis factor alpha cDNA. Young AJ, et al. Nucleic Acids Res, 1990 Nov 25. PMID 2251151, Free PMC Article
  2. Molecular cloning, expression and characterization of ovine TNF alpha. Nash AD, et al. Immunol Cell Biol, 1991 Aug. PMID 1786996
  3. Sequence of the cDNA encoding ovine tumor necrosis factor-alpha: problems with cloning by inverse PCR. Green IR, et al. Gene, 1991 Dec 30. PMID 1765267
  4. Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion? Hodges PW, et al. Spine (Phila Pa 1976), 2014 Jun 1. PMID 24718080
  5. Tumor necrosis factor-alpha and acute-phase proteins in early pregnant ewes after challenge with peptidoglycan-polysaccharide. Dow TL, et al. Domest Anim Endocrinol, 2010 Aug. PMID 20603027

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The aim of the study was to assess the prognostic significance of Tumor Necrosis Factor-alpha, Interleukin-12(p40), Interleukin-6 and Interleukin 10 levels in cerebrospinal fluid (CSF) in sheep with encephalitic listeriosis.
    Title: Tumor Necrosis Factor-α, Interleukins-12(p40), 6, and 10 levels in cerebrospinal fluid and outcome prediction in Ossimi sheep with encephalitic listeriosis.
  2. The p38 MAPK inhibitor decreased (P < 0.01) gene expression of TNFa but its effect was not observed at the level of TNFa protein synthesis
    Title: Peripheral injection of SB203580 inhibits the inflammatory-dependent synthesis of proinflammatory cytokines in the hypothalamus.
  3. TNF-alpha gene expression in multifidus was greater on both sides in the disc lesion animals than in the muscle of control animals.
    Title: Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion?
  4. Injection of peptidoglycan-polysaccharide resulted in fever, increased concentrations of TNF-alpha on the day of and the day after challenge, and decreased concentrations of progesterone on days 14 and 21.
    Title: Tumor necrosis factor-alpha and acute-phase proteins in early pregnant ewes after challenge with peptidoglycan-polysaccharide.
  5. plasma IL-1 beta, TNF-alpha and MCP-1 may potentially serve as markers to monitor prognosis of pregnancy toxaemia in ewes
    Title: Elevated plasma levels of interleukin 1 beta, tumour necrosis factor alpha and monocyte chemotactic protein 1 are associated with pregnancy toxaemia in ewes.
  6. These data are consistent with the effects of LPS on GH secretion originating through peripheral cytokine presentation to the pituitary, as well as a potential to act directly on selective populations of pituitary cells via CD14.
    Title: Interleukin-1beta and tumor necrosis factor-alpha mediation of endotoxin action on growth hormone.
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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CD40 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor
Names
TNF-a
cachectin
tumor necrosis factor (TNF superfamily, member 2)
tumor necrosis factor alpha
tumor necrosis factor ligand superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024860.1 → NP_001020031.1  tumor necrosis factor

    See identical proteins and their annotated locations for NP_001020031.1

    Status: PROVISIONAL

    Source sequence(s)
    X56756
    UniProtKB/Swiss-Prot
    P23383
    UniProtKB/TrEMBL
    A5YBV0
    Related
    ENSOARP00020020594.1, ENSOART00020024817.2
    Conserved Domains (1) summary
    pfam00229
    Location:103 → 234
    TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056073.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    26798126..26800865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23383.2 GenPept UniProtKB/Swiss-Prot:P23383

Gene LinkOut

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