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IL12B interleukin 12B [ Ovis aries (sheep) ]

Gene ID: 443472, updated on 5-Mar-2024

Summary

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Gene symbol
IL12B
Gene description
interleukin 12B
See related
EnsemblRapid:ENSOARG00020023587
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
IL-12
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 5 NC_056058.1 (68475587..68490841, complement)

Chromosome 5 - NC_056058.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 145 Neighboring gene transfer RNA phenylalanine (anticodon AAA) Neighboring gene ubiquitin like domain containing CTD phosphatase 1 Neighboring gene uncharacterized LOC121819669 Neighboring gene U4 spliceosomal RNA Neighboring gene transfer RNA cysteine (anticodon ACA)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056058.1 Chromosome 5 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ovine interleukin-12: analysis of biologic function and species comparison. De Rose R, et al. J Interferon Cytokine Res, 2000 Jun. PMID 10888112
  2. Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium. Klebe S, et al. J Immunol, 2005 Aug 15. PMID 16081789
  3. Tumor Necrosis Factor-α, Interleukins-12(p40), 6, and 10 levels in cerebrospinal fluid and outcome prediction in Ossimi sheep with encephalitic listeriosis. Abdlla OA, et al. Cytokine, 2015 Jun. PMID 25817420
  4. Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cells. Swinburne SJ, et al. Cytokine, 2000 Oct. PMID 11023671
  5. Sequence diversity and rates of molecular evolution between sheep and cattle genes. Kijas JW, et al. Anim Genet, 2006 Apr. PMID 16573533

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The aim of the study was to assess the prognostic significance of Tumor Necrosis Factor-alpha, Interleukin-12(p40), Interleukin-6 and Interleukin 10 levels in cerebrospinal fluid (CSF) in sheep with encephalitic listeriosis.
    Title: Tumor Necrosis Factor-α, Interleukins-12(p40), 6, and 10 levels in cerebrospinal fluid and outcome prediction in Ossimi sheep with encephalitic listeriosis.
  2. Local intraocular production of IL-12 p40 (but not IL-4) prolongs corneal graft survival significantly
    Title: Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-12 subunit beta
Names
CLMF p40
IL-12 subunit p40
IL-12B
cytotoxic lymphocyte maturation factor 40 kDa subunit
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
interleukin-12 p40 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009438.1 → NP_001009438.1  interleukin-12 subunit beta precursor

    See identical proteins and their annotated locations for NP_001009438.1

    Status: PROVISIONAL

    Source sequence(s)
    AF004024
    UniProtKB/Swiss-Prot
    P68220
    UniProtKB/TrEMBL
    W5PUF3
    Related
    ENSOARP00020051988.1, ENSOART00020076180.1
    Conserved Domains (4) summary
    smart00408
    Location:42 → 90
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:42 → 91
    IG_like; Immunoglobulin like
    cd00063
    Location:236 → 324
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam10420
    Location:126 → 217
    IL12p40_C; Cytokine interleukin-12p40 C-terminus

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056058.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    68475587..68490841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042249406.1 → XP_042105340.1  interleukin-12 subunit beta isoform X1

    UniProtKB/TrEMBL
    W5PUF3
    Related
    ENSOARP00020037410.1, ENSOART00020065981.1
    Conserved Domains (2) summary
    smart00408
    Location:42 → 90
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:236 → 324
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68220.1 GenPept UniProtKB/Swiss-Prot:P68220

Gene LinkOut

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