CAST calpastatin [Ovis aries (sheep)] - Gene

Summary

Gene symbol: CAST
Gene description: calpastatin
See related: EnsemblRapid:ENSOARG00020012132
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Ovis aries
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	ARS-UI_Ramb_v3.0 (GCF_016772045.2)	5	NC_056058.1 (93695915..93785491)

Chromosome 5 - NC_056058.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_056058.1 Chromosome 5 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Breeding efforts aimed at the improvement of lamb meat quality should prioritize the selection of the "ac" CAST genotype. The loins of rams with "ac" genotype had the highest intramuscular fat content, indicative of beneficial health-related properties and technological usefulness.
Title: Association of CAST gene polymorphism with carcass value and meat quality in two synthetic lines of sheep.
CAST and GDF-8 genes are associated with lower values of lamb meat tenderness and is related to the stage of muscular growth and development.
Title: Expression of calpastatin and myostatin genes associated with lamb meat quality.
calpastatin gene single nucleotide polymorphisms and haplotypes in Iranian fat- and thin-tailed sheep breeds and their effects on it's protein structure
Title: Detecting novel SNPs and breed-specific haplotypes at calpastatin gene in Iranian fat- and thin-tailed sheep breeds and their effects on protein structure.
Study reports that there was no significant association between variation in CAST and either longevity or fertility in sheep.
Title: No association between variation in the ovine calpastatin gene and either longevity or fertility in sheep.
Calpastatin gene is associated with birth weight and growth rate to weaning.
Title: Association of the ovine calpastatin gene with birth weight and growth rate to weaning.
no significant association between tenderness in un-aged lamb and either the CAST alleles or genotypes
Title: Lack of association between CAST SNPs and meat tenderness in sheep.
SSCP variations detected might have an impact on both the function and expression of ovine calpastatin.
Title: Polymorphism of the ovine calpastatin gene.

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General gene information

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Markers

CALPASTAT-2 (e-PCR)
- UniSTS:254059

CAST (e-PCR), detects polymorphism
- UniSTS:505002

CAST-2 (e-PCR), detects polymorphism
- UniSTS:253905

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium-dependent cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inhibition of cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: calpastatin

Names: calpain inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.