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SCD stearoyl-CoA desaturase [ Ovis aries (sheep) ]

Gene ID: 443185, updated on 5-Mar-2024

Summary

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Gene symbol
SCD
Gene description
stearoyl-CoA desaturase
See related
EnsemblRapid:ENSOARG00020023857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
SCD1
Orthologs
human all
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Genomic context

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See SCD in Genome Data Viewer
Location:
chromosome: 22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 22 NC_056075.1 (21026048..21038058)

Chromosome 22 - NC_056075.1Genomic Context describing neighboring genes Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 2 Neighboring gene polycystin 2 like 1, transient receptor potential cation channel Neighboring gene uncharacterized LOC106991766 Neighboring gene Wnt family member 8B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056075.1 Chromosome 22 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reductions in milk Δ9-desaturation ratios to oral dosing of cobalt-acetate are accompanied by the downregulation of SCD1 in lactating ewes. Toral PG, et al. J Dairy Sci, 2015 Mar. PMID 25547303
  2. Identifying novel SNPs and allelic sequences of the stearoyl-CoA desaturase gene (SCD) in fat-tailed and thin-tailed sheep breeds. Aali M, et al. Biochem Genet, 2014 Apr. PMID 24271826
  3. Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome. Ward RJ, et al. Biochim Biophys Acta, 1998 Mar 30. PMID 9554990
  4. MicroRNA-432 inhibits milk fat synthesis by targeting SCD and LPL in ovine mammary epithelial cells. Hao Z, et al. Food Funct, 2021 Oct 4. PMID 34606535
  5. Detection of quantitative trait loci affecting the milk fatty acid profile on sheep chromosome 22: role of the stearoyl-CoA desaturase gene in Spanish Churra sheep. García-Fernández M, et al. J Dairy Sci, 2010 Jan. PMID 20059933

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-432 inhibits milk fat synthesis by targeting SCD and LPL in ovine mammary epithelial cells.
    Title: MicroRNA-432 inhibits milk fat synthesis by targeting SCD and LPL in ovine mammary epithelial cells.
  2. Co dosing lowered the mRNA abundance of SCD1 in the mammary secretory tissue (33%), whereas no changes were detected in the SCD5 isoform or in the studied transcription factors (SREBF1, PPARG, SP1, and EGR2).
    Title: Reductions in milk Δ9-desaturation ratios to oral dosing of cobalt-acetate are accompanied by the downregulation of SCD1 in lactating ewes.
  3. determined the existence of polymorphisms in the stearoyl-coenzyme A-desaturase gene in 458 lambs belonging to three traditional fat-tailed, medium fat-tailed, and thin-tailed Iranian sheep breeds.
    Title: Identifying novel SNPs and allelic sequences of the stearoyl-CoA desaturase gene (SCD) in fat-tailed and thin-tailed sheep breeds.
  4. stearoyl-CoA desaturase
    Title: Detection of quantitative trait loci affecting the milk fatty acid profile on sheep chromosome 22: role of the stearoyl-CoA desaturase gene in Spanish Churra sheep.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables palmitoyl-CoA 9-desaturase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables stearoyl-CoA 9-desaturase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to fatty acid IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
acyl-CoA desaturase
Names
delta(9)-desaturase
fatty acid desaturase
NP_001009254.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009254.1 → NP_001009254.1  acyl-CoA desaturase

    See identical proteins and their annotated locations for NP_001009254.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ001048
    UniProtKB/Swiss-Prot
    O62849
    UniProtKB/TrEMBL
    C0JXB7
    Related
    ENSOARP00020030811.1, ENSOART00020037219.2
    Conserved Domains (2) summary
    cd03505
    Location:97 → 337
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:101 → 306
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056075.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    21026048..21038058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62849.1 GenPept UniProtKB/Swiss-Prot:O62849

Gene LinkOut

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