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NOS2 nitric oxide synthase 2 [ Ovis aries (sheep) ]

Gene ID: 443078, updated on 5-Mar-2024

Summary

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Gene symbol
NOS2
Gene description
nitric oxide synthase 2
See related
EnsemblRapid:ENSOARG00020024251
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
INOS; NOS2A
Orthologs
human mouse all
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Genomic context

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See NOS2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (19316341..19358972, complement)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132657331 Neighboring gene galectin 9 Neighboring gene uncharacterized LOC121820565 Neighboring gene LYR motif containing 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The inhibition of inducible nitric oxide synthase in ovine sepsis model. Enkhbaatar P, et al. Shock, 2006 May. PMID 16680018
  2. Developmental changes in nitric oxide synthesis in the ovine placenta. Kwon H, et al. Biol Reprod, 2004 Mar. PMID 14613894
  3. Estrogen increases iNOS expression in the ovine coronary artery. Mershon JL, et al. Am J Physiol Heart Circ Physiol, 2002 Sep. PMID 12181148
  4. Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype. Kameny RJ, et al. Am J Physiol Heart Circ Physiol, 2015 Jul 1. PMID 25934095, Free PMC Article
  5. Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury. Cox RA, et al. Exp Lung Res, 2009 Mar. PMID 19263280, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There was increased RNA and protein expression of NOS isoforms and increased total NOS activity in the RV of both cardiac L-R shunt and fetal lambs compared with control. This is a preserved fetal NOS phenotype and NO signaling in shunt RV.
    Title: Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype.
  2. pulmonary expression of nitric oxide synthase isoforms in an ovine model of acute lung injury induced by smoke inhalation and burn injury
    Title: Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury.
  3. high degree of metabolic coordination among the several integrated pathways that support high rates of NO synthesis in the conceptus and uterus
    Title: Developmental changes in nitric oxide synthesis in the ovine placenta.
  4. iNOS may be partially involved in the pathogenesis of acute lung injury induced by smoke inhalation followed by bacterial instillation in the airway
    Title: The inhibition of inducible nitric oxide synthase in ovine sepsis model.
  5. All three isoforms of NOS are constitutively expressed infetal brainstem. Expression is reduced with advancing gestation. Reduced expression of NOS in this brain region may play role in increased fetal baroreflex activity in late gestation. (nos1, 2, 3)
    Title: Expression of nitric oxide synthase isoforms is reduced in late-gestation ovine fetal brainstem.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nitric oxide synthase, inducible
Names
inducible nitric oxide synthase
nitric oxide synthase 2, inducible
nitric oxide synthase 2A (inducible, hepatocytes)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    19316341..19358972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042255454.1 → XP_042111388.1  nitric oxide synthase, inducible isoform X1

    UniProtKB/TrEMBL
    A0A835ZXC3, W5Q5J6
    Related
    ENSOARP00020031594.2, ENSOART00020038156.2
    Conserved Domains (3) summary
    cd00795
    Location:84 → 496
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cl00438
    Location:577 → 656
    FMN_red; NADPH-dependent FMN reductase
    cl06868
    Location:736 → 1132
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  2. XM_012185382.5 → XP_012040772.2  nitric oxide synthase, inducible isoform X2

    UniProtKB/TrEMBL
    W5Q5J6
Nucleotide Protein Strain
Heading Accession and Version

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