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CAPN3 calpain 3 [ Ovis aries (sheep) ]

Gene ID: 443038, updated on 5-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
EnsemblRapid:ENSOARG00020015778
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
nCL1; SKM-CALPOV
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (35937305..35993187)

Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 87A Neighboring gene uncharacterized LOC121820065 Neighboring gene glucosidase alpha, neutral C Neighboring gene uncharacterized LOC132660178 Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23 Neighboring gene leucine rich repeat containing 57

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigation of biochemical changes of the ovine calpain 3 exon-10 polymorphism. Muto Y, et al. Mol Cell Probes, 2015 Dec. PMID 26363096
  2. Variation in ovine CAPN3 is not associated with meat tenderness. Zhou H, et al. Anim Genet, 2009 Apr. PMID 19133936
  3. Effect of variants in the ovine skeletal-muscle-specific calpain gene on body weight. Chung H, et al. J Appl Genet, 2007. PMID 17272862
  4. Single nucleotide polymorphisms of the ovine calpain 3 (CAPN3) gene. Zhou H, et al. Mol Cell Probes, 2007 Feb. PMID 16954051
  5. Effect of preslaughter feed withdrawal period on longissimus tenderness and the expression of calpains in the ovine. Ilian MA, et al. J Agric Food Chem, 2001 Apr. PMID 11308358

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that the reported association of specific allele variants within CAPN3 exon-10 to phenotype variations were not direct effects of CAPN3 polymorphisms.
    Title: Investigation of biochemical changes of the ovine calpain 3 exon-10 polymorphism.
  2. Variation in CAPN3 is not associated with meat tenderness.
    Title: Variation in ovine CAPN3 is not associated with meat tenderness.
  3. Sequence analysis revealed that the polymorphic patterns represented three allelic sequences of ovine calpain 3.
    Title: Single nucleotide polymorphisms of the ovine calpain 3 (CAPN3) gene.
  4. Calpain 3 genotypes of the CAPN31112 segment were associated with birth weight (P < 0.01), and a dominant gene effect was observed.
    Title: Effect of variants in the ovine skeletal-muscle-specific calpain gene on body weight.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3
Names
CANP 3
calcium-activated neutral proteinase 3
calpain 3, (p94)
calpain L3
calpain p94
muscle-specific calcium-activated neutral protease 3
nCL-1
new calpain 1
skeletal muscle-specific calpain
NP_001009212.1
XP_042107868.1
XP_042107869.1
XP_042107870.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009212.1 → NP_001009212.1  calpain-3

    See identical proteins and their annotated locations for NP_001009212.1

    Status: PROVISIONAL

    Source sequence(s)
    AF087570
    UniProtKB/Swiss-Prot
    O97701, Q9TTH8
    UniProtKB/TrEMBL
    A0A836A381, W5QH59
    Related
    ENSOARP00020020450.2, ENSOART00020024656.2
    Conserved Domains (5) summary
    cd00051
    Location:698 → 752
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:75 → 416
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:430 → 580
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:584 → 654
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:729 → 818
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    35937305..35993187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042251934.2 → XP_042107868.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A836A381, W5QH59
    Conserved Domains (3) summary
    smart00230
    Location:61 → 426
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:428 → 585
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16190
    Location:610 → 778
    EFh_PEF_CAPN3; Calcium-activated neutral

  2. XM_042251935.2 → XP_042107869.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A836A381, W5QH59
    Conserved Domains (3) summary
    smart00230
    Location:61 → 377
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:379 → 536
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16190
    Location:605 → 773
    EFh_PEF_CAPN3; Calcium-activated neutral

  3. XM_042251936.2 → XP_042107870.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A836A381, W5QH59
    Conserved Domains (3) summary
    smart00230
    Location:61 → 377
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:379 → 536
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16190
    Location:561 → 729
    EFh_PEF_CAPN3; Calcium-activated neutral
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TTH8.1 GenPept UniProtKB/Swiss-Prot:Q9TTH8

Gene LinkOut

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