MIR196B microRNA 196b [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR196Bprovided by HGNC
Official Full Name: microRNA 196bprovided by HGNC
Primary source: HGNC:HGNC:31790
See related: Ensembl:ENSG00000283745 MIM:609688; miRBase:MI0001150; AllianceGenome:HGNC:31790
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN196B; miR-196b; miRNA196B
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7p15.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (27169480..27169563, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (27305489..27305572, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (27209099..27209182, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-196b-5p regulates inflammatory process and migration via targeting Nras in trabecular meshwork cells.
Title: miR-196b-5p regulates inflammatory process and migration via targeting Nras in trabecular meshwork cells.
Upregulation of miRNA-196a and miRNA-196b correlates with Bryne's prognostic score in oral squamous cell carcinoma.
Title: Upregulation of miRNA-196a and miRNA-196b correlates with Bryne's prognostic score in oral squamous cell carcinoma.
METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b.
Title: METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b.
Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.
Title: Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.
Long noncoding RNA FGD5-AS1 alleviates childhood IgA nephropathy by targeting PTEN-mediated JNK/c-Jun signaling pathway via miR-196b-5p.
Title: Long noncoding RNA FGD5-AS1 alleviates childhood IgA nephropathy by targeting PTEN-mediated JNK/c-Jun signaling pathway via miR-196b-5p.
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1alpha loop.
Title: Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop.
[Effect of Negative Regulation of LncRNA XIST to MiR-196b on the Biological Behavior of Acute Myeloid Leukemia Cells KG1a].
Title: [Effect of Negative Regulation of LncRNA XIST to MiR-196b on the Biological Behavior of Acute Myeloid Leukemia Cells KG1a].
MicroRNA-196b promotes cell growth and metastasis of ovarian cancer by targeting ZMYND11.
Title: MicroRNA-196b promotes cell growth and metastasis of ovarian cancer by targeting ZMYND11.
miR-196b-5p and miR-107 Expression Differentiates Ocular Sebaceous Carcinoma from Squamous Cell Carcinoma of the Conjunctiva.
Title: miR-196b-5p and miR-107 Expression Differentiates Ocular Sebaceous Carcinoma from Squamous Cell Carcinoma of the Conjunctiva.
Effect and Role of miR-196b in Ectopic Pregnancy.
Title: Effect and Role of miR-196b in Ectopic Pregnancy.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Markers

ECD01564 (e-PCR)
- UniSTS:282667

ECD16827 (e-PCR)
- UniSTS:297842

RH80053 (e-PCR)
- UniSTS:83907

REN100636 (e-PCR)
- UniSTS:425433

REN100637 (e-PCR)
- UniSTS:425434

REN100638 (e-PCR)
- UniSTS:425435

REN100639 (e-PCR)
- UniSTS:425436

REN100640 (e-PCR)
- UniSTS:425437

REN100641 (e-PCR)
- UniSTS:425438

REN100642 (e-PCR)
- UniSTS:425439

REN100643 (e-PCR)
- UniSTS:425440

REN100644 (e-PCR)
- UniSTS:425441

REN100645 (e-PCR)
- UniSTS:425442

REN100646 (e-PCR)
- UniSTS:425443

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in miRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.