SoxN SoxNeuro [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SoxNprovided by FlyBase
Official Full Name: SoxNeuroprovided by FlyBase
Primary source: FLYBASE:FBgn0029123
Locus tag: Dmel_CG18024
See related: AllianceGenome:FB:FBgn0029123
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18024; DM64; Dmel\CG18024; Sox B1; SOX29F; SOXB1; soxN; soxNeuro; Sry-rDM64
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and chromatin DNA binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; nervous system development; and regionalization. Located in nucleus. Is expressed in several structures, including central nervous system; ectoderm; ectoderm anlage; epidermis; and extended germ band embryo. Used to study X-linked panhypopituitarism. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX1 (SRY-box transcription factor 1) and SOX2 (SRY-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 29F2-29F2; 2-34 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8825645..8829670)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8825645..8829670)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
Title: Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
Co-expressing ectopic SoxN with svb rescued diverse denticle morphologies. Conversely, removing SoxN activity eliminated the residual denticles found in svb mutant embryos. Furthermore, several known Svb target genes are also activated by SoxN, and we have discovered two novel target genes of SoxN that are expressed in denticle-producing cells and that are regulated independently of Svb.
Title: SoxNeuro and Shavenbaby act cooperatively to shape denticles in the embryonic epidermis of Drosophila.
Functionsl analysis places SoxN at the heart of the regulatory networks driving neural specification and differentiation.
Title: SoxNeuro orchestrates central nervous system specification and differentiation in Drosophila and is only partially redundant with Dichaete.
SoxN is necessary and sufficient to cell-autonomously direct the expression of svb.
Title: The Drosophila HMG-domain proteins SoxNeuro and Dichaete direct trichome formation via the activation of shavenbaby and the restriction of Wingless pathway activity.
SoxN is directly involved in axonal patterning
Title: Chromatin immunoprecipitation reveals a novel role for the Drosophila SoxNeuro transcription factor in axonal patterning.
Evidence for differential and redundant function of the Sox genes during CNS development in Drosophila
Title: Evidence for differential and redundant function of the Sox genes Dichaete and SoxN during CNS development in Drosophila.
Controls formation of neuroblasts in the embryonic central nervous system of Drosophila melanogaster
Title: Formation of neuroblasts in the embryonic central nervous system of Drosophila melanogaster is controlled by SoxNeuro.
SUMO represses transcriptional activity of SoxN.
Title: SUMO represses transcriptional activity of the Drosophila SoxNeuro and human Sox3 central nervous system-specific transcription factors.
SoxN repression is potentiated by adding ectopic Tcf, suggesting that SoxN interacts with the repressor form of Tcf to influence Wg/Wnt target gene transcription.
Title: The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based larval cuticle pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SoxNeuro

Names: CG18024-PA; CG18024-PB; Sox-neuro; SoxN-PA; SoxN-PB; Sry-related DM64; soxneuro

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

8825645..8829670

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079996.3 → NP_524735.1 SoxNeuro, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524735.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1H5, Q9VLH8

Related

FBpp0079335

Conserved Domains (1) summary

cd01388
Location:178 → 249

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001273340.2 → NP_001260269.1 SoxNeuro, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260269.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCZ7

Conserved Domains (1) summary

cd01388
Location:178 → 249

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...