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Sara Smad anchor for receptor activation [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44263, updated on 18-Sep-2024

Summary

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Official Symbol
Saraprovided by FlyBase
Official Full Name
Smad anchor for receptor activationprovided by FlyBase
Primary source
FLYBASE:FBgn0026369
Locus tag
Dmel_CG15667
See related
AllianceGenome:FB:FBgn0026369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15667; Dmel\CG15667; dSARA; sara; SARA
Summary
Enables protein phosphatase 1 binding activity. Involved in asymmetric stem cell division; intestinal stem cell homeostasis; and stem cell fate determination. Located in early endosome. Orthologous to several human genes including ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sara in Genome Data Viewer
Location:
57E6-57E6; 2-95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21481927..21487107)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17369432..17374612)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A oxidase at 57D proximal Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene Syndecan Neighboring gene FK506-binding protein 14 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division. Loubéry S, et al. Nat Commun, 2017 Jun 6. PMID 28585564, Free PMC Article
  2. Target-selected mutant screen by TILLING in Drosophila. Winkler S, et al. Genome Res, 2005 May. PMID 15867432, Free PMC Article
  3. Cell biology. Sara splits the signal. Knoblich JA. Science, 2006 Nov 17. PMID 17110561
  4. Uninflatable and Notch control the targeting of Sara endosomes during asymmetric division. Loubéry S, et al. Curr Biol, 2014 Sep 22. PMID 25155514
  5. Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity. Chong PA, et al. J Biol Chem, 2004 Sep 24. PMID 15231848

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. upon phosphorylation of Sara, endosomes detach from the spindle during pIIa targeting.
    Title: Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division.
  2. Notch binds Uninflatable, and both traffic together through Sara endosomes, which is essential to direct asymmetric endosomes motility and Notch-dependent cell fate assignation.
    Title: Uninflatable and Notch control the targeting of Sara endosomes during asymmetric division.
  3. Sara itself contributes to the control of the intestinal stem cells asymmetric division.
    Title: Sara endosomes and the asymmetric division of intestinal stem cells.
  4. asymmetric targeting of Delta and Notch-containing Sara endosomes will increase Notch signalling in sensory organ precursor daughter cell, pIIa, and decrease it in pIIb
    Title: Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division.
  5. PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster.
    Title: PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster.
  6. During mitosis, Sara endosomes associate with the spindle machinery to segregate into the two daughter cells, daughter cells thereby inherited equal amounts of signaling molecules and retained the Dpp signaling levels of the mother cell
    Title: Sara endosomes and the maintenance of Dpp signaling levels across mitosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
smad anchor for receptor activation
Names
CG15667-PA
Sara-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21481927..21487107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079990.3 → NP_524729.2  smad anchor for receptor activation [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524729.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K9H6, Q960V6
    Related
    FBpp0071564
    Conserved Domains (3) summary
    cd15729
    Location:522 → 589
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:614 → 650
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:959 → 1321
    DUF3480; Domain of unknown function (DUF3480)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K9H6 Q7K9H6
Q960V6 Q960V6

Gene LinkOut

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