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SULT1C3 sulfotransferase family 1C member 3 [ Homo sapiens (human) ]

Gene ID: 442038, updated on 5-Mar-2024

Summary

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Official Symbol
SULT1C3provided by HGNC
Official Full Name
sulfotransferase family 1C member 3provided by HGNC
Primary source
HGNC:HGNC:33543
See related
Ensembl:ENSG00000196228 MIM:617151; AllianceGenome:HGNC:33543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST1C3
Summary
Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process; cholesterol metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
2q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (108239968..108265351)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (108700880..108726238)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (108856424..108881807)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1594 Neighboring gene SET domain containing 6 pseudogene 1 Neighboring gene WASF1 pseudogene 1 Neighboring gene sulfotransferase family 1C member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human Cytosolic Sulphotransferase SULT1C3: genomic analysis and functional characterization of splice variant SULT1C3a and SULT1C3d. Kurogi K, et al. J Biochem, 2017 Dec 1. PMID 28992322, Free PMC Article
  2. Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. Duniec-Dmuchowski Z, et al. Drug Metab Dispos, 2014 Mar. PMID 24335392, Free PMC Article
  3. Transcriptional Regulation of Human Cytosolic Sulfotransferase 1C3 by Peroxisome Proliferator-Activated Receptor γ in LS180 Human Colorectal Adenocarcinoma Cells. Dubaisi S, et al. Mol Pharmacol, 2016 Nov. PMID 27565680, Free PMC Article
  4. Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells. Rondini EA, et al. Drug Metab Dispos, 2014 Mar. PMID 24335393, Free PMC Article
  5. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. Meinl W, et al. Food Chem Toxicol, 2008 Apr. PMID 17936463

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPARgamma regulatory network includes SULT1C3 and imply that this enzyme contributes to the control of such PPARgamma-regulated intestinal processes as growth, differentiation, and metabolism.
    Title: Transcriptional Regulation of Human Cytosolic Sulfotransferase 1C3 by Peroxisome Proliferator-Activated Receptor γ in LS180 Human Colorectal Adenocarcinoma Cells.
  2. Our findings are the first to characterize the regulation of human SULT1C2 and SULT1C3 expression by several transcription factor activators.
    Title: Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.
  3. These data indicate that SULT1C3 is expressed in human intestine.
    Title: Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sulfotransferase 1C3
Names
sulfotransferase family, cytosolic, 1C, member 3
NP_001008743.1
NP_001307807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008743.3 → NP_001008743.1  sulfotransferase 1C3 isoform 2

    See identical proteins and their annotated locations for NP_001008743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus but is the same length as isoform 1.
    Source sequence(s)
    AC019100
    Consensus CDS
    CCDS33267.1
    UniProtKB/Swiss-Prot
    Q6IMI5, Q6IMI6
    Related
    ENSP00000333310.2, ENST00000329106.3
    Conserved Domains (1) summary
    pfam00685
    Location:46 → 297
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001320878.2 → NP_001307807.1  sulfotransferase 1C3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).
    Source sequence(s)
    AC019100
    Consensus CDS
    CCDS92828.1
    UniProtKB/Swiss-Prot
    Q6IMI6
    Related
    ENSP00000505748.1, ENST00000681802.2
    Conserved Domains (1) summary
    pfam00685
    Location:46 → 297
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. NR_178047.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant 1 but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding since the primary ORF has a stop codon >50 nucleotides from the terminal splice site; nonsense-mediated mRNA decay (NMD) candidate.
    Source sequence(s)
    CP068276

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    108239968..108265351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    108700880..108726238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IMI6.1 GenPept UniProtKB/Swiss-Prot:Q6IMI6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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