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SPANXN4 SPANX family member N4 [ Homo sapiens (human) ]

Gene ID: 441525, updated on 5-Mar-2024

Summary

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Official Symbol
SPANXN4provided by HGNC
Official Full Name
SPANX family member N4provided by HGNC
Primary source
HGNC:HGNC:33177
See related
Ensembl:ENSG00000189326 MIM:300667; AllianceGenome:HGNC:33177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT11.9
Summary
This gene represents one of several duplicated family members that are located on the X chromosome. This gene family encodes proteins that play a role in spermiogenesis. These proteins represent a specific subgroup of cancer/testis-associated antigens, and they may be candidates for tumor vaccines. This family member belongs to a subgroup of related genes that are present in all primates and rats and mice, and thus, it represents one of the ancestral family members. [provided by RefSeq, Sep 2009]
Expression
Restricted expression toward testis (RPKM 3.2) See more
Orthologs
all
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Genomic context

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Location:
Xq27.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (143025928..143038637)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (141334566..141347275)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (142113714..142122097)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373345 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:141891706-141892905 Neighboring gene small nucleolar RNA U13 Neighboring gene RN7SK pseudogene 81 Neighboring gene NANOG hESC enhancer GRCh37_chrX:142252945-142253661 Neighboring gene RN7SK pseudogene 149

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. Westbrook VA, et al. Mol Hum Reprod, 2006 Nov. PMID 17012309
  2. The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. Kouprina N, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14973187, Free PMC Article
  3. The protein interaction landscape of the human CMGC kinase group. Varjosalo M, et al. Cell Rep, 2013 Apr 25. PMID 23602568
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
sperm protein associated with the nucleus on the X chromosome N4
Names
cancer/testis antigen family 11, member 9
nuclear-associated protein SPAN-Xn4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013264.1 RefSeqGene

    Range
    5011..13394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009613.4 → NP_001009613.1  sperm protein associated with the nucleus on the X chromosome N4

    See identical proteins and their annotated locations for NP_001009613.1

    Status: REVIEWED

    Source sequence(s)
    AL137840, BC130503
    Consensus CDS
    CCDS48178.1
    UniProtKB/Swiss-Prot
    Q0ZNK6, Q5MJ08, Q5W0S6
    Related
    ENSP00000405210.1, ENST00000446864.2
    Conserved Domains (1) summary
    pfam07458
    Location:1 → 89
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    143025928..143038637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029543.1 → XP_016885032.1  sperm protein associated with the nucleus on the X chromosome N4 isoform X1

  2. XM_017029544.1 → XP_016885033.1  sperm protein associated with the nucleus on the X chromosome N4 isoform X2

    UniProtKB/TrEMBL
    X6R7N2
    Related
    ENSP00000359535.3, ENST00000370504.3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    141334566..141347275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327106.1 → XP_054183081.1  sperm protein associated with the nucleus on the X chromosome N4 isoform X1

  2. XM_054327107.1 → XP_054183082.1  sperm protein associated with the nucleus on the X chromosome N4 isoform X2

    UniProtKB/TrEMBL
    X6R7N2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5MJ08.1 GenPept UniProtKB/Swiss-Prot:Q5MJ08

Gene LinkOut

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