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mAcon1 Mitochondrial aconitase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44149, updated on 2-Nov-2024

Summary

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Official Symbol
mAcon1provided by FlyBase
Official Full Name
Mitochondrial aconitase 1provided by FlyBase
Primary source
FLYBASE:FBgn0010100
Locus tag
Dmel_CG9244
See related
AllianceGenome:FB:FBgn0010100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
acon; Acon; ACON-1; aconitase; AconM; BEST:GH10550; CG9244; Dmel\CG9244; hsp60; i204; i59; l(2)07054; m-acon; m-Acon; M-Acon; mAc; mAcon; mACON
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and aconitate hydratase activity. Involved in tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Used to study Parkinson's disease and infantile cerebellar-retinal degeneration. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mAcon1 in Genome Data Viewer
Location:
39A7-39A7; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21168570..21173185)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21168570..21173185)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene burgundy

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Das N, et al. Biochem J, 2001 Nov 15. PMID 11696009, Free PMC Article
  2. Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency. Cheng Z, et al. Biochem Biophys Res Commun, 2013 Mar 29. PMID 23438437
  3. Mitochondrial aconitase 1 regulates age-related memory impairment via autophagy/mitophagy-mediated neural plasticity in middle-aged flies. Cho YH, et al. Aging Cell, 2021 Dec. PMID 34799973, Free PMC Article
  4. Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Wu Z, et al. Neurobiol Aging, 2012 Jan. PMID 20674094
  5. Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging. Paul A, et al. Mech Ageing Dev, 2007 Nov-Dec. PMID 18078670, Free PMC Article

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables aconitate hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aconitate hydratase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IC
Inferred by Curator
more info
 PubMed 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial aconitase 1
Names
ACONITASE
CG9244-PB
CG9244-PD
CG9244-PE
CG9244-PF
m-aconitase
mAcon1-PB
mAcon1-PD
mAcon1-PE
mAcon1-PF
mitochondrial aconitase
NP_001097186.2
NP_001163030.1
NP_001286119.1
NP_524708.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21168570..21173185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299190.1 → NP_001286119.1  mitochondrial aconitase 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286119.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NFX1, Q9VIE8
    Conserved Domains (3) summary
    cd01584
    Location:102 → 513
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:595 → 743
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:52 → 782
    aconitase_mito; aconitate hydratase, mitochondrial

  2. NM_001103716.2 → NP_001097186.2  mitochondrial aconitase 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097186.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NFX1, Q9VIE8
    Conserved Domains (3) summary
    cd01584
    Location:102 → 513
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:595 → 743
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:52 → 782
    aconitase_mito; aconitate hydratase, mitochondrial

  3. NM_001169559.2 → NP_001163030.1  mitochondrial aconitase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163030.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NFX1, Q9VIE8
    Conserved Domains (3) summary
    cd01584
    Location:102 → 513
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:595 → 743
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:52 → 782
    aconitase_mito; aconitate hydratase, mitochondrial

  4. NM_079969.5 → NP_524708.1  mitochondrial aconitase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NFX1, Q9VIE8
    Related
    FBpp0081002
    Conserved Domains (3) summary
    cd01584
    Location:102 → 513
    AcnA_Mitochondrial; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
    cd01578
    Location:595 → 743
    AcnA_Mitochon_Swivel; Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes ...
    TIGR01340
    Location:52 → 782
    aconitase_mito; aconitate hydratase, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NFX0 Q9NFX0
Q9VIE8 Q9VIE8

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