U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Optix optix [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44108, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Optixprovided by FlyBase
Official Full Name
optixprovided by FlyBase
Primary source
FLYBASE:FBgn0025360
Locus tag
Dmel_CG18455
See related
AllianceGenome:FB:FBgn0025360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.79; CG18455; D-Six3; Dmel\CG18455; Dsix3; opt; optix; OPTIX; opx; six3; Six3
Summary
Enables sequence-specific DNA binding activity. Involved in compound eye photoreceptor cell differentiation; dendrite morphogenesis; and progression of morphogenetic furrow involved in compound eye morphogenesis. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; head epidermis primordium; head segment; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in holoprosencephaly; holoprosencephaly 2; and optic disc anomalies with retinal and/or macular dystrophy. Orthologous to several human genes including SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Optix in Genome Data Viewer
Location:
44A3-44A3; 2-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8031283..8042529)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3918788..3930034)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45267 Neighboring gene long non-coding RNA:CR43724 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Shared and distinct mechanisms of atonal regulation in Drosophila ocelli and compound eyes. Zhou Q, et al. Dev Biol, 2016 Oct 1. PMID 27565023, Free PMC Article
  2. Six3 demarcates the anterior-most developing brain region in bilaterian animals. Steinmetz PR, et al. Evodevo, 2010 Dec 29. PMID 21190549, Free PMC Article
  3. The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes. Jacobs J, et al. Nat Genet, 2018 Jul. PMID 29867222, Free PMC Article
  4. Cellular and behavioral functions of fruitless isoforms in Drosophila courtship. von Philipsborn AC, et al. Curr Biol, 2014 Feb 3. PMID 24440391, Free PMC Article
  5. The non-conserved C-terminal segments of Sine Oculis Homeobox (SIX) proteins confer functional specificity. Weasner BP, et al. Genesis, 2009 Aug. PMID 19422020, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anteroposterior patterning of Drosophila ocelli requires an anti-repressor mechanism within the hh pathway mediated by the Six3 gene Optix.
    Title: Anteroposterior patterning of Drosophila ocelli requires an anti-repressor mechanism within the hh pathway mediated by the Six3 gene Optix.
  2. optix functions together with hh to regulate dpp in the morphogenetic furrow, serving as a link between the RD network and the patterning pathways controlling normal retinal development
    Title: optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila.
  3. Data suggest that during early phases of eye development, So and Optix function, in part, to repress the transcription of non-retinal selector genes, thereby allowing induction of the retina to proceed.
    Title: Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development.
  4. different cofactors likely mediate unique functions of Sine oculis and Optix during the development of the fly eye
    Title: Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development.
  5. Sine oculis mutation within the Six domain does not abolish DNA-protein interactions, but alters co-factor binding specificity to resemble that of Optix
    Title: Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in compound eye development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
optix
Names
CG18455-PA
CG18455-PB
CG18455-PC
Optix-PA
Optix-PB
Optix-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8031283..8042529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273864.2 → NP_001260793.1  optix, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEE9
    Conserved Domains (2) summary
    cd00086
    Location:158 → 206
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:37 → 150
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

  2. NM_079956.3 → NP_524695.2  optix, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524695.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76291, Q8MKN3, Q95RW8, Q9UA64, Q9V355
    Related
    FBpp0087941
    Conserved Domains (2) summary
    cd00086
    Location:158 → 206
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:37 → 150
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

  3. NM_165584.2 → NP_724640.1  optix, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RW8
    Related
    FBpp0087942
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEE9 A0A0B4KEE9
Q95RW8.1 Q95RW8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools