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MIAT myocardial infarction associated transcript [ Homo sapiens (human) ]

Gene ID: 440823, updated on 5-Mar-2024

Summary

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Official Symbol
MIATprovided by HGNC
Official Full Name
myocardial infarction associated transcriptprovided by HGNC
Primary source
HGNC:HGNC:33425
See related
Ensembl:ENSG00000225783 MIM:611082; AllianceGenome:HGNC:33425
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNCR2; GOMAFU; C22orf35; LINC00066; NCRNA00066; lncRNA-MIAT
Summary
This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]
Expression
Biased expression in brain (RPKM 36.1), adrenal (RPKM 14.9) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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See MIAT in Genome Data Viewer
Location:
22q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (26646429..26676478)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (27109028..27139053)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (27053446..27072441)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27003362-27004004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13574 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:27009656-27010334 Neighboring gene crystallin beta A4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27013045-27013722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27014401-27015076 Neighboring gene crystallin beta B1 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1058 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27037805-27038669 Neighboring gene Sharpr-MPRA regulatory region 8650 Neighboring gene Sharpr-MPRA regulatory region 12592 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27041123-27041688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27043802-27044604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27045408-27046209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18797 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:27057049-27058028 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:27061097-27061597 Neighboring gene iron-sulfur cluster assembly 2 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27063956-27064539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27064540-27065122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27076707-27077531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27077532-27078355 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:27085634-27086255 Neighboring gene MIAT neighbor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18799 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27146977-27147974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27147975-27148973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27148974-27149971 Neighboring gene Sharpr-MPRA regulatory region 13066 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:27179387-27180586 Neighboring gene Sharpr-MPRA regulatory region 7329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27196413-27196924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18800 Neighboring gene Sharpr-MPRA regulatory region 5469 Neighboring gene uncharacterized LOC110091768 Neighboring gene ribosomal protein L15 pseudogene 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition. Zhan Y, et al. Commun Biol, 2023 Mar 18. PMID 36934152, Free PMC Article
  2. The LncRNA MIAT is identified as a regulator of stemness-associated transcript in glioma. Amirmahani F, et al. Mol Biol Rep, 2023 Jan. PMID 36352177
  3. Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation. Khan MM, et al. Front Immunol, 2022. PMID 35784351, Free PMC Article
  4. The Long Non-Coding RNA GOMAFU in Schizophrenia: Function, Disease Risk, and Beyond. Zakutansky PM, et al. Cells, 2022 Jun 17. PMID 35741078, Free PMC Article
  5. lncRNA MIAT targets miR-411-5p/STAT3/PD-L1 axis mediating hepatocellular carcinoma immune response. Zhang X, et al. Int J Exp Pathol, 2022 Jun. PMID 35429078, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke.
    Title: lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke.
  2. LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.
    Title: LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.
  3. MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.
    Title: MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.
  4. Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X.
    Title: Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X.
  5. The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
    Title: The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
  6. LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition.
    Title: LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition.
  7. The LncRNA MIAT is identified as a regulator of stemness-associated transcript in glioma.
    Title: The LncRNA MIAT is identified as a regulator of stemness-associated transcript in glioma.
  8. Downregulation of Long Noncoding RNA Myocardial Infarction Associated Transcript Suppresses Cell Proliferation, Migration, Invasion, and Glycolysis by Regulation of miR-488-3p/IGF1R Pathway in Colorectal Cancer.
    Title: Downregulation of Long Noncoding RNA Myocardial Infarction Associated Transcript Suppresses Cell Proliferation, Migration, Invasion, and Glycolysis by Regulation of miR-488-3p/IGF1R Pathway in Colorectal Cancer.
  9. Variation in the expression level of MALAT1, MIAT and XIST lncRNAs in coronary artery disease patients with and without type 2 diabetes mellitus.
    Title: Variation in the expression level of MALAT1, MIAT and XIST lncRNAs in coronary artery disease patients with and without type 2 diabetes mellitus.
  10. Novel insights into bicuspid aortic valve (BAV) aortopathy: Long non-coding RNAs TUG1 and MIAT are differentially expressed in BAV ascending aortas.
    Title: Novel insights into bicuspid aortic valve (BAV) aortopathy: Long non-coding RNAs TUG1 and MIAT are differentially expressed in BAV ascending aortas.
Submit: New GeneRIF Correction See all GeneRIFs (83)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Myocardial infarction, susceptibility to
MedGen: C1832662 OMIM: 608446 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • MI related novel mRNA
  • long intergenic non-protein coding RNA 66
  • myocardial infarction associated transcript (non-protein coding)

Clone Names

  • FLJ25887, FLJ25967, FLJ38367, FLJ45323

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016621.2 RefSeqGene

    Range
    5001..23997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_003491.4 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774
    Related
    ENST00000613780.4

  2. NR_033319.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774
    Related
    ENST00000616469.4

  3. NR_033320.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774
    Related
    ENST00000620145.5

  4. NR_033321.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774
    Related
    ENST00000616213.4

  5. NR_185982.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  6. NR_185983.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  7. NR_185984.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  8. NR_185985.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  9. NR_185986.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  10. NR_185987.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  11. NR_185988.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  12. NR_185989.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  13. NR_185990.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  14. NR_185991.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  15. NR_185993.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  16. NR_185994.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  17. NR_185995.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  18. NR_185996.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  19. NR_185997.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

  20. NR_185998.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    KF511428, Z99774

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    26646429..26676478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    27109028..27139053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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