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TRIM67 tripartite motif containing 67 [ Homo sapiens (human) ]

Gene ID: 440730, updated on 17-Mar-2024

Summary

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Official Symbol
TRIM67provided by HGNC
Official Full Name
tripartite motif containing 67provided by HGNC
Primary source
HGNC:HGNC:31859
See related
Ensembl:ENSG00000119283 MIM:610584; AllianceGenome:HGNC:31859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNL
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of protein localization. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 4.1) and adrenal (RPKM 0.2) See more
Orthologs
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Genomic context

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Location:
1q42.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (231162058..231221565)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (230544922..230604828)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231297804..231357311)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 4 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:231174678-231175359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1948 Neighboring gene family with sequence similarity 89 member A Neighboring gene CRISPRi-validated cis-regulatory element chr1.12443 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12444 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12445 Neighboring gene Sharpr-MPRA regulatory region 4964 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12446 Neighboring gene peptidylprolyl isomerase A like 4C pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:231298070-231298704 Neighboring gene NANOG hESC enhancer GRCh37_chr1:231319561-231320089 Neighboring gene TRIM67 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231350707-231351208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231352923-231353422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231356573-231357073 Neighboring gene chromosome 1 open reading frame 131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2725 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:231376971-231377860 Neighboring gene glyceronephosphate O-acyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease. Huang C, et al. Int J Mol Sci, 2022 Jul 5. PMID 35806477, Free PMC Article
  2. TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression. Wang S, et al. Cancer Res, 2019 Aug 15. PMID 31239268
  3. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. Short KM, et al. J Biol Chem, 2006 Mar 31. PMID 16434393
  4. Mammalian TRIM67 Functions in Brain Development and Behavior. Boyer NP, et al. eNeuro, 2018 May-Jun. PMID 29911180, Free PMC Article
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 67
Names
TRIM9-like protein TNL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004342.5 → NP_001004342.3  tripartite motif-containing protein 67 isoform 1

    See identical proteins and their annotated locations for NP_001004342.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109810, AL137801
    Consensus CDS
    CCDS44333.1
    UniProtKB/Swiss-Prot
    Q5TER7, Q5TER8, Q6ZTA4, Q7Z4K7
    Related
    ENSP00000355613.5, ENST00000366653.6
    Conserved Domains (5) summary
    smart00502
    Location:347 → 473
    BBC; B-Box C-terminal domain
    cd00063
    Location:528 → 604
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:301 → 340
    zf-B_box; B-box zinc finger
    cd12889
    Location:601 → 772
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cl17238
    Location:7 → 45
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_001300889.3 → NP_001287818.1  tripartite motif-containing protein 67 isoform 2

    See identical proteins and their annotated locations for NP_001287818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame segments in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL109810, AL137801
    Consensus CDS
    CCDS73048.1
    UniProtKB/Swiss-Prot
    Q6ZTA4
    Related
    ENSP00000400163.3, ENST00000449018.7
    Conserved Domains (5) summary
    smart00502
    Location:285 → 411
    BBC; B-Box C-terminal domain
    cd00063
    Location:466 → 542
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:239 → 278
    zf-B_box; B-box zinc finger
    cd12889
    Location:539 → 710
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cl17238
    Location:7 → 30
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. NM_001410937.1 → NP_001397866.1  tripartite motif-containing protein 67 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL109810, AL137801
    Consensus CDS
    CCDS91173.1
    UniProtKB/TrEMBL
    F8W8C1
    Related
    ENSP00000412124.3, ENST00000444294.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    231162058..231221565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    230544922..230604828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZTA4.3 GenPept UniProtKB/Swiss-Prot:Q6ZTA4

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