U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HNRNPCL2 heterogeneous nuclear ribonucleoprotein C like 2 [ Homo sapiens (human) ]

Gene ID: 440563, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
HNRNPCL2provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein C like 2provided by HGNC
Primary source
HGNC:HGNC:48813
See related
Ensembl:ENSG00000275774 AllianceGenome:HGNC:48813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRNPCP5
Summary
Enables identical protein binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HNRNPCL2 in Genome Data Viewer
Location:
1p36.21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (13115488..13116854, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12628805..12630171)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13182960..13184326, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 34, pseudogene Neighboring gene PRAME family member 35, pseudogene Neighboring gene PRAME family member 36, pseudogene Neighboring gene PRAME family member 26

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity. Ruiz M, et al. J Biol Chem, 2023 Jun. PMID 37164154, Free PMC Article
  2. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. Van Quickelberghe E, et al. Sci Data, 2018 Dec 18. PMID 30561431, Free PMC Article
  3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375, Free PMC Article
  4. TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1. Zhou J, et al. J Cell Biol, 2023 Feb 6. PMID 36574265, Free PMC Article
  5. The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers. Oravcová M, et al. Elife, 2022 Nov 14. PMID 36373674, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
heterogeneous nuclear ribonucleoprotein C-like 2
Names
heterogeneous nuclear ribonucleoprotein C pseudogene 5
hnRNP C-like-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136561.3 → NP_001130033.3  heterogeneous nuclear ribonucleoprotein C-like 2

    See identical proteins and their annotated locations for NP_001130033.3

    Status: VALIDATED

    Source sequence(s)
    BC144551, BC157858
    Consensus CDS
    CCDS76105.1
    UniProtKB/Swiss-Prot
    B2RXH8, B7ZW41
    UniProtKB/TrEMBL
    A0A0G2JNQ3
    Related
    ENSP00000479203.2, ENST00000621994.3
    Conserved Domains (1) summary
    cd12341
    Location:16 → 83
    RRM_hnRNPC_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein C (hnRNP C)-related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    13115488..13116854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_012132914.1 Reference GRCh38.p14 PATCHES

    Range
    269828..271194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_015495298.1 Reference GRCh38.p14 PATCHES

    Range
    111104..112470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187517.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    61031..62397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12628805..12630171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RXH8.1 GenPept UniProtKB/Swiss-Prot:B2RXH8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools