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NPIPB15 nuclear pore complex interacting protein family member B15 [ Homo sapiens (human) ]

Gene ID: 440348, updated on 28-Oct-2024

Summary

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Official Symbol
NPIPB15provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B15provided by HGNC
Primary source
HGNC:HGNC:34409
See related
Ensembl:ENSG00000196436 AllianceGenome:HGNC:34409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIPL2; A-761H5.4
Summary
Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis (RPKM 17.7), skin (RPKM 3.0) and 23 other tissues See more
Orthologs
all
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Genomic context

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See NPIPB15 in Genome Data Viewer
Location:
16q23.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (74376306..74392115)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (80194084..80209885)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (74410204..74426013)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 118 Neighboring gene prostate cancer associated HIP1 interacting lncRNA Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit 2, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74390671-74391172 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:74402112-74402363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11107 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:74414879-74415096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74431311-74432152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74433981-74434480 Neighboring gene uncharacterized LOC105376772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74441122-74442022 Neighboring gene C-type lectin domain family 18 member B Neighboring gene uncharacterized LOC107984827

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member B15
Names
nuclear pore complex interacting protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306094.2 → NP_001293023.1  nuclear pore complex-interacting protein family member B15 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001293023.1

    Status: VALIDATED

    Source sequence(s)
    AC009053
    Consensus CDS
    CCDS76897.1
    UniProtKB/Swiss-Prot
    A6NHN6, C9J9U8
    UniProtKB/TrEMBL
    I3L0I5
    Related
    ENSP00000508772.1, ENST00000692376.1
    Conserved Domains (1) summary
    pfam06409
    Location:23 → 299
    NPIP; Nuclear pore complex interacting protein (NPIP)

  2. NM_001385737.1 → NP_001372666.1  nuclear pore complex-interacting protein family member B15 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC009053
    UniProtKB/TrEMBL
    I3L0I5
    Conserved Domains (1) summary
    pfam06409
    Location:37 → 306
    NPIP; Nuclear pore complex interacting protein (NPIP)

  3. NM_001385738.1 → NP_001372667.1  nuclear pore complex-interacting protein family member B15 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009053
    UniProtKB/TrEMBL
    O75199
    Conserved Domains (1) summary
    pfam06409
    Location:12 → 177
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    74376306..74392115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434161.1 → XP_047290117.1  nuclear pore complex-interacting protein family member B15 isoform X1

  2. XM_017023248.1 → XP_016878737.1  nuclear pore complex-interacting protein family member B15 isoform X2

    UniProtKB/Swiss-Prot
    A6NHN6, C9J9U8
    UniProtKB/TrEMBL
    I3L0I5
    Related
    ENSP00000411140.1, ENST00000429990.1
    Conserved Domains (1) summary
    pfam06409
    Location:23 → 299
    NPIP; Nuclear pore complex interacting protein (NPIP)

  3. XM_047434162.1 → XP_047290118.1  nuclear pore complex-interacting protein family member B15 isoform X3

  4. XM_047434164.1 → XP_047290120.1  nuclear pore complex-interacting protein family member B15 isoform X6

  5. XM_024450290.1 → XP_024306058.1  nuclear pore complex-interacting protein family member B15 isoform X4

    UniProtKB/TrEMBL
    O75199
    Conserved Domains (1) summary
    pfam06409
    Location:23 → 160
    NPIP; Nuclear pore complex interacting protein (NPIP)

  6. XM_047434163.1 → XP_047290119.1  nuclear pore complex-interacting protein family member B15 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    80194084..80209885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380384.1 → XP_054236359.1  nuclear pore complex-interacting protein family member B15 isoform X2

    UniProtKB/Swiss-Prot
    A6NHN6, C9J9U8

  2. XM_054380385.1 → XP_054236360.1  nuclear pore complex-interacting protein family member B15 isoform X4

  3. XM_054380386.1 → XP_054236361.1  nuclear pore complex-interacting protein family member B15 isoform X7

  4. XM_054380387.1 → XP_054236362.1  nuclear pore complex-interacting protein family member B15 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018059.2: Suppressed sequence

    Description
    NM_001018059.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NHN6.3 GenPept UniProtKB/Swiss-Prot:A6NHN6

Gene LinkOut

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