Pten Phosphatase and tensin homolog [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptenprovided by FlyBase
Official Full Name: Phosphatase and tensin homologprovided by FlyBase
Primary source: FLYBASE:FBgn0026379
Locus tag: Dmel_CG5671
See related: AllianceGenome:FB:FBgn0026379
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5671; D.PTEN; Dmel\CG5671; dpten; dPten; dPTEN; DPTEN; pten; pTEN; PTEN; PTEN3
Summary: Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein serine/threonine phosphatase activity. Involved in several processes, including negative regulation of hemocyte differentiation; negative regulation of signal transduction; and regulation of neuron projection development. Located in endosome membrane. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; medullary zone of lymph gland primary lobe; and organism. Used to study cancer and disease of metabolism. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 31B1-31B1; 2-40 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10256319..10261049, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10256319..10261049, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.
Title: Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila.
Our findings identify a novel PTEN/dPLCXD pathway that controls PtdIns(4,5)P2 levels on endosomes. They also point to a potential new strategy for the treatment of Lowe syndrome.
Title: PTEN reduces endosomal PtdIns(4,5)P(2) in a phosphatase-independent manner via a PLC pathway.
Here we show that PTEN mutation impacts aPKC and Lgl protein levels also in Drosophila. Moreover, we demonstrate that PI3K activation is not sufficient to trigger tumourigenesis, while aPKC promotes hyperplastic growth of the neuroepithelium and a noticeable expansion of the type II neuroblasts.
Title: Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila.
Ectopic expression of dPTEN (a phosphatase and tensin homologue) in the fat body prolongs fruit fly life.
Title: Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.
PTEN deficient cells proliferate under conditions of nutrient restriction.
Title: Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues.
loss of the tumor suppressor PTEN disrupts cell rearrangements by preventing the lengthening of newly formed junctions that become unstable and keep on rearranging
Title: PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue.
study demonstrates that in the Drosophila lymph gland the tumor suppressors TSC and PTEN control blood progenitor proliferation through a common TOR- and 4EBP-dependent pathway
Title: Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors.
Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Title: Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam.
Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells.
Title: Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines.
A mutation in the pleckstrin homology (PH) domain of Akt that reduces its affinity for PIP3 sufficed to rescue the lethality of flies devoid of PTEN activity.
Title: Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphoprotein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine/serine/threonine phosphatase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell fate determination, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut histolysis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatase and tensin homolog

Names: CG5671-PA; CG5671-PB; CG5671-PC; CG5671-PD; CG5671-PE; CG5671-PG; CG5671-PH; PI 3-phosphatase; PTEN; PtdIns(3,4,5)P3 phosphatase; Pten-PA; Pten-PB; Pten-PC; Pten-PD; Pten-PE; Pten-PG; Pten-PH; drosophila phosphatase and tensin homologue deleted on chromosome 10; phosphatase and tensin homologue; phosphatidylinositol (3,4,5)-trisphosphate phosphatase

NP_001162933.1

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NP_477422.2

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NP_477423.1

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NP_477424.1

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NP_599147.1

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NP_599148.1

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NP_599149.1

EC 3.1.3.-

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.67

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10256319..10261049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058075.4 → NP_477423.1 phosphatase and tensin homolog, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477423.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMQ6, Q9U469, Q9Y0B5

Related

FBpp0088843

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_134320.3 → NP_599147.1 phosphatase and tensin homolog, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599147.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U468, Q9U470, Q9V3L4

Related

FBpp0088844

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_058074.4 → NP_477422.2 phosphatase and tensin homolog, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477422.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMQ6, Q9U469, Q9Y0B5

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_058076.4 → NP_477424.1 phosphatase and tensin homolog, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477424.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y0B6

Related

FBpp0088841

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_134322.3 → NP_599149.1 phosphatase and tensin homolog, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599149.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMQ6, Q9U469, Q9Y0B5

Related

FBpp0088839

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_134321.3 → NP_599148.1 phosphatase and tensin homolog, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599148.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U468, Q9U470, Q9V3L4

Related

FBpp0088840

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001169462.2 → NP_001162933.1 phosphatase and tensin homolog, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162933.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMQ6, Q9U469, Q9Y0B5

Conserved Domains (2) summary

pfam10409
Location:196 → 335

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21483
Location:58 → 167

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...