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Lip1 Lipase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43973, updated on 2-Nov-2024

Summary

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Official Symbol
Lip1provided by FlyBase
Official Full Name
Lipase 1provided by FlyBase
Primary source
FLYBASE:FBgn0023496
Locus tag
Dmel_CG7279
See related
AllianceGenome:FB:FBgn0023496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7279; dLip1; Dmel\CG7279; Dmlip1; Lip; lip1; LIP1Dm
Summary
Predicted to enable triacylglycerol lipase activity. Involved in digestion. Is expressed in several structures, including embryonic/larval posterior spiracle; eye disc posterior to the morphogenetic furrow; gut section; larval muscle system; and primary tracheal branch. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Lip1 in Genome Data Viewer
Location:
32A4-32A4; 2-43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10699408..10701544, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10699408..10701544, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44181 Neighboring gene uncharacterized protein Neighboring gene Lipase 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
  2. dFOXO regulates transcription of a Drosophila acid lipase. Vihervaara T, et al. J Mol Biol, 2008 Mar 7. PMID 18234213
  3. Female sterile mutations and egg chamber development in Drosophila melanogaster. Gigliotti S, et al. Int J Dev Biol, 2000. PMID 11061421
  4. Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. Goodliffe JM, et al. BMC Mol Biol, 2007 May 22. PMID 17519021, Free PMC Article
  5. Immunity regulatory DNAs share common organizational features in Drosophila. Senger K, et al. Mol Cell, 2004 Jan 16. PMID 14731391

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in digestion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
lipase 1
Names
CG7279-PA
CG7279-PB
Lip1-PA
Lip1-PB
Lipase1
NP_001285811.1
NP_523540.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10699408..10701544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078816.4 → NP_523540.1  lipase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523540.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46107, Q9VKR6
    UniProtKB/TrEMBL
    X2JDS0
    Related
    FBpp0079713
    Conserved Domains (2) summary
    pfam00561
    Location:103 → 399
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:71 → 122
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

  2. NM_001298882.1 → NP_001285811.1  lipase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285811.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46107, Q9VKR6
    UniProtKB/TrEMBL
    X2JDS0
    Conserved Domains (2) summary
    pfam00561
    Location:103 → 399
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:71 → 122
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46107.2 O46107
X2JDS0 X2JDS0

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