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a arc [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43852, updated on 28-Oct-2024

Summary

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Official Symbol
aprovided by FlyBase
Official Full Name
arcprovided by FlyBase
Primary source
FLYBASE:FBgn0000008
Locus tag
Dmel_CG6741
See related
AllianceGenome:FB:FBgn0000008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Arc; bran; CG13505; CG6741; Dmel\CG6741
Summary
Involved in compound eye development. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including Malpighian tubule; embryonic/larval salivary gland; eye disc morphogenetic furrow; gut section; and imaginal disc. Orthologous to human LNX1 (ligand of numb-protein X 1); LNX2 (ligand of numb-protein X 2); and STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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Location:
58C1-58C5; 2-98 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22136968..22172834)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18024473..18060339)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Golgi matrix protein 130 kD Neighboring gene uncharacterized protein Neighboring gene NtR Neighboring gene uncharacterized protein Neighboring gene gomdanji Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45151 Neighboring gene uncharacterized protein Neighboring gene F-box protein 42 Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CoFly: A gene coexpression database for the fruit fly Drosophila melanogaster. Liu W, et al. Arch Insect Biochem Physiol, 2020 Sep. PMID 32436316
  2. New facts on dependent, successive and conjugated spontaneous mutation. GOLDSCHMIDT RB. J Exp Zool, 1947 Mar. PMID 20290998
  3. Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling. Miyashita T, et al. Cell Rep, 2018 Dec 4. PMID 30517860
  4. The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth. Szuplewski S, et al. Development, 2003 Aug. PMID 12835382
  5. The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development. Goossens T, et al. Development, 2011 Apr. PMID 21389050, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arc
Names
CG6741-PA
CG6741-PB
CG6741-PC
CG6741-PD
a-PA
a-PB
a-PC
a-PD
broad angular

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22136968..22172834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166514.2 → NP_726168.1  arc, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726168.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W283, Q9W284
    Related
    FBpp0071677
    Conserved Domains (1) summary
    cd00992
    Location:1230 → 1317
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001014543.2 → NP_001014543.1  arc, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W283, Q9W284
    Conserved Domains (1) summary
    cd00992
    Location:1230 → 1317
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. NM_001299777.1 → NP_001286706.1  arc, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286706.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG21
    Conserved Domains (1) summary
    cd00992
    Location:988 → 1075
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. NM_079902.3 → NP_524641.1  arc, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W283, Q9W284
    Related
    FBpp0071678
    Conserved Domains (1) summary
    cd00992
    Location:1230 → 1317
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LG21 A0A0B4LG21
Q9W283 Q9W283

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