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dati datilografo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43789, updated on 18-Sep-2024

Summary

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Official Symbol
datiprovided by FlyBase
Official Full Name
datilografoprovided by FlyBase
Primary source
FLYBASE:FBgn0262636
Locus tag
Dmel_CG2052
See related
AllianceGenome:FB:FBgn0262636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10204; CG2052; Dmel\CG2052; DmLin29; Lin29
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in adult locomotory behavior; nervous system development; and positive regulation of female receptivity. Predicted to be active in nucleus. Is expressed in adult brain; embryonic abdomen; embryonic brain; and embryonic/larval nervous system. Orthologous to human ZBTB48 (zinc finger and BTB domain containing 48) and ZNF142 (zinc finger protein 142). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See dati in Genome Data Viewer
Location:
102B6-102B7; 4-0 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (375640..395605, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (396266..416231, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Ring finger protein 11 Neighboring gene plasma membrane calcium ATPase Neighboring gene Host cell factor Neighboring gene long non-coding RNA:CR45125 Neighboring gene antisense RNA:CR44027 Neighboring gene mir-9385 stem loop Neighboring gene long non-coding RNA:CR43437

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel genetic tool for clonal analysis of fourth chromosome mutations. Sousa-Neves R, et al. Fly (Austin), 2012 Jan-Mar. PMID 22198523, Free PMC Article
  2. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
  3. The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females. Schinaman JM, et al. PLoS Biol, 2014 Oct. PMID 25291190, Free PMC Article
  4. Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors. Tsuji T, et al. Development, 2008 Dec. PMID 18948419
  5. Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster. Sidorenko DS, et al. Chromosoma, 2019 Jun. PMID 31041520, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. required for proper locomotion and courtship acceptance in adult Drosophila females
    Title: The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c379721-379034 mobile_element_type = transposon:INE-1{}5512
  • Loc: c381698-381620 mobile_element_type = transposon:INE-1{}5513
  • Loc: c392037-391697 mobile_element_type = transposon:INE-1{}5529

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in generation of neurons IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of female receptivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
datilografo
Names
CG2052-PA
CG2052-PB
CG2052-PC
CG2052-PD
dati-PA
dati-PB
dati-PC
dati-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    375640..395605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258492.3 → NP_001245421.1  datilografo, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245421.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3X3, Q7KQN5
    Conserved Domains (4) summary
    COG5048
    Location:429 → 511
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:667 → 687
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:454 → 478
    zf-H2C2_2; Zinc-finger double domain

  2. NM_166758.4 → NP_726568.2  datilografo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726568.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3X3, Q95U52, Q9V4C9
    Related
    FBpp0088197
    Conserved Domains (4) summary
    COG5048
    Location:429 → 587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:657 → 677
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:454 → 478
    zf-H2C2_2; Zinc-finger double domain

  3. NM_205874.3 → NP_995596.1  datilografo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3X3, Q7KQN5
    Conserved Domains (4) summary
    COG5048
    Location:429 → 511
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:667 → 687
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:454 → 478
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001258493.2 → NP_001245422.1  datilografo, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245422.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9XVN7
    Conserved Domains (3) summary
    COG5048
    Location:70 → 152
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:82 → 102
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:95 → 119
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H9XVN7 H9XVN7
Q7K3X3 Q7K3X3
Q7KQN5 Q7KQN5
Q9V4C9 Q9V4C9

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