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salt salty dog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43742, updated on 2-Nov-2024

Summary

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Official Symbol
saltprovided by FlyBase
Official Full Name
salty dogprovided by FlyBase
Primary source
FLYBASE:FBgn0039872
Locus tag
Dmel_CG2196
See related
AllianceGenome:FB:FBgn0039872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2196; Dmel\CG2196; dSLC5A7
Summary
Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Located in basolateral plasma membrane. Is expressed in Malpighian tubule Type I cell; adult Malpighian tubule; adult head; and adult main segment of Malpighian tubule. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See salt in Genome Data Viewer
Location:
100D2-100D2; 3-102 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31751825..31754705, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27577547..27580427, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene abnormal wing discs Neighboring gene nero Neighboring gene uncharacterized protein Neighboring gene mir-1014 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44263

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endurance exercise protects aging Drosophila from high-salt diet (HSD)-induced climbing capacity decline and lifespan decrease by enhancing antioxidant capacity. Wen DT, et al. Biol Open, 2020 May 29. PMID 32414766, Free PMC Article
  2. Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heart salt-specific overexpression in Drosophila. Wen DT, et al. Aging (Albany NY), 2021 Aug 12. PMID 34383711, Free PMC Article
  3. Drosophila exercise, an emerging model bridging the fields of exercise and aging in human. Ding M, et al. Front Cell Dev Biol, 2022. PMID 36158212, Free PMC Article
  4. Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Stergiopoulos K, et al. Physiol Genomics, 2009 Mar 3. PMID 19018044, Free PMC Article
  5. Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila. Dus M, et al. Nat Neurosci, 2013 May. PMID 23542692, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
salty dog
Names
CG2196-PB
CG2196-PC
salt-PB
salt-PC
salty

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31751825..31754705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300697.1 → NP_001287626.1  salty dog, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287626.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHY2, Q95SK1
    Conserved Domains (1) summary
    cd11492
    Location:28 → 565
    SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain

  2. NM_143632.4 → NP_651889.3  salty dog, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651889.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SK1, Q9V9U2
    Conserved Domains (1) summary
    cd11492
    Location:28 → 566
    SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHY2 A0A0B4LHY2
Q95SK1 Q95SK1
Q9V9U2 Q9V9U2

Gene LinkOut

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