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ORF10 ORF10 protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740576, updated on 6-Oct-2024

Summary

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Gene symbol
ORF10
Gene description
ORF10 protein
Locus tag
GU280_gp11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF10 encodes a potential viral accessory protein.
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Genomic context

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Sequence:
NC_045512.2 (29558..29674)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene ORF8 protein Neighboring gene nucleocapsid phosphoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phylogenetically conserved hairpin-type 3' untranslated region pseudoknot functions in coronavirus RNA replication. Williams GD, et al. J Virol, 1999 Oct. PMID 10482585, Free PMC Article
  2. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2. Hassan SS, et al. Int J Biol Macromol, 2021 Jun 30. PMID 33862077, Free PMC Article
  3. Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function. Hassan SS, et al. Int J Biol Macromol, 2022 Jan 1. PMID 34863825, Free PMC Article
  4. SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites. Zhu K, et al. Acta Pharm Sin B, 2024 Sep. PMID 39309499, Free PMC Article
  5. Structural insights into ORF10 recognition by ZYG11B. Zhang B, et al. Biochem Biophys Res Commun, 2022 Aug 6. PMID 35636250, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10.
    Title: Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10.
  2. Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.
    Title: Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.
  3. Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.
    Title: Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.
  4. ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
    Title: ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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stem_loop

  • Loc: 29609-29644 function = Coronavirus 3' UTR pseudoknot stem-loop 1 , inference = COORDINATES: profile::Rfam-release-14.1:RF00165,Infernal:1.1.2
  • Loc: 29629-29657 function = Coronavirus 3' UTR pseudoknot stem-loop 2 , inference = COORDINATES: profile::Rfam-release-14.1:RF00165,Infernal:1.1.2

General protein information

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Preferred Names
ORF10 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    29558..29674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009725255.1 ORF10 protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A663DJA2
    UniProtKB/TrEMBL
    A0A6B9W2G5, A0A6H0C3G7, A0A6H0C3M3, A0A6M4MS97, A0A6M6JX05, A0A6N1WF36, A0A7D5LGE1, A0A7D5TPW4, A0A7G5WXS9, A0A7H2DSJ7, A0A7L8K8N1, A0A7U0IQ92, A0A7U1M855, A0A899XSP3, A0A8A5Q5C3, A0A8A7ZXU9, A0A8B1JF83, A0A8B1JZ25, A0A8B6RWK7
    Conserved Domains (1) summary
    cd21597
    Location:1 → 36
    SARS-CoV-2_Orf10; Severe acute respiratory syndrome coronavirus 2 Orf10
Nucleotide Protein
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Gene LinkOut

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