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ORF6 ORF6 protein [ Severe acute respiratory syndrome coronavirus 2 ]

Gene ID: 43740572, updated on 6-Jun-2024

Summary

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Gene symbol
ORF6
Gene description
ORF6 protein
Locus tag
GU280_gp06
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Severe acute respiratory syndrome coronavirus 2 (isolate: Wuhan-Hu-1, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
Summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF6 encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF6 protein is thought to play a role in viral pathogenesis.
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Genomic context

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Sequence:
NC_045512.2 (27202..27387)

NC_045512.2Genomic Context describing neighboring genes Neighboring gene envelope protein Neighboring gene membrane glycoprotein Neighboring gene ORF7a protein Neighboring gene ORF7b Neighboring gene ORF8 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045512.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France. Quéromès G, et al. Emerg Microbes Infect, 2021 Dec. PMID 33399033, Free PMC Article
  2. Deubiquitinase USP1 regulates sarbecovirus ORF6 protein function. Gao W, et al. J Virol, 2024 Jan 23. PMID 38084957, Free PMC Article
  3. Dysregulation of intracellular redox homeostasis by the SARS-CoV-2 ORF6 protein. De Angelis M, et al. Virol J, 2023 Oct 18. PMID 37853388, Free PMC Article
  4. SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists. Yuen CK, et al. Emerg Microbes Infect, 2020 Dec. PMID 32529952, Free PMC Article
  5. Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system. Suleman M, et al. Front Immunol, 2023. PMID 38283360, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.
    Title: SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport.
  2. Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system.
    Title: Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system.
  3. Deubiquitinase USP1 regulates sarbecovirus ORF6 protein function.
    Title: Deubiquitinase USP1 regulates sarbecovirus ORF6 protein function.
  4. Dysregulation of intracellular redox homeostasis by the SARS-CoV-2 ORF6 protein.
    Title: Dysregulation of intracellular redox homeostasis by the SARS-CoV-2 ORF6 protein.
  5. Insights into the SARS-CoV-2 ORF6 Mechanism of Action.
    Title: Insights into the SARS-CoV-2 ORF6 Mechanism of Action.
  6. Analysis of SARS-CoV-2 Spike Protein Variants with Recombinant Reporter Viruses Created from a Bacmid System.
    Title: Analysis of SARS-CoV-2 Spike Protein Variants with Recombinant Reporter Viruses Created from a Bacmid System.
  7. SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
    Title: SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export.
  8. SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98.
    Title: SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98.
  9. Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France.
    Title: Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France.
  10. Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.
    Title: Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
ORF6 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_045512.2 Reference assembly

    Range
    27202..27387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009724394.1 ORF6 protein [Severe acute respiratory syndrome coronavirus 2]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0DTC6
    UniProtKB/TrEMBL
    A0A6B9W0L4, A0A6C0R2B4, A0A6H1XM06, A0A6M3WHL2, A0A6M4N5D9, A0A6M4NGE3, A0A6M5CCW3, A0A6M6D2N8, A0A6N0W0U0, A0A6N1NQ14, A0A6N1WL69, A0A6V7AKS8, A0A6V7ANX7, A0A7L7QV71, A0A7L9W1S1, A0A7M1G0F3, A0A7U0ISC5, A0A7U1D8Z3, A0A7U1QYE3, A0A7U2CMY6, A0A883GNR7, A0A899K4H0, A0A8A2R2E6, A0A8A9L4E0, A0A8B1KKK3
    Conserved Domains (1) summary
    pfam12133
    Location:1 → 61
    Sars6; Open reading frame 6 from SARS coronavirus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTC6.1 P0DTC6

Gene LinkOut

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