pygo pygopus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pygoprovided by FlyBase
Official Full Name: pygopusprovided by FlyBase
Primary source: FLYBASE:FBgn0043900
Locus tag: Dmel_CG11518
See related: AllianceGenome:FB:FBgn0043900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO02077023.1; BEST:LD21971; CG11518; Dm Pygo; Dmel\CG11518; dPygo; gam; pNB5.2; pyg; Pygo; pypo
Summary: Enables methylated histone binding activity and transcription coactivator activity. Involved in several processes, including instar larval or pupal development; positive regulation of transcription by RNA polymerase II; and segment polarity determination. Located in nucleus. Part of beta-catenin-TCF complex. Is expressed in cardioblast and organism. Used to study heart conduction disease. Orthologous to human PYGO1 (pygopus family PHD finger 1) and PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 100C6-100C6; 3-102 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31575835..31580699, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27401557..27406421, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila.
Title: Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila.
Structure and function of Pygo in organ development dependent and independent Wnt signalling.
Title: Structure and function of Pygo in organ development dependent and independent Wnt signalling.
The authors use a proteomics approach to discover the Chip/LDB-SSDP (ChiLS) complex as the ligand specifically binding to NPF motif of Pygo proteins.
Title: An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.
results are consistent with the idea that pygo functions independently of canonical Wnt signaling in the differentiation of the adult interchamber cardiac valves
Title: The role of pygopus in the differentiation of intracardiac valves in Drosophila.
humanized fly Pygo derepresses Notch targets, implying an inherent Notch-related function of classical Pygo orthologs, disabled in fly Pygo, which thus appears dedicated to Wnt signaling.
Title: Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2.
Double knockdown of pygo and Ca2+/calmodulin-dependent protein kinase II caused additional arrhythmia compared with pygo knockdown alone, suggesting that some of the effects of pygo are mediated by Ca2+ signaling.
Title: Pygopus maintains heart function in aging Drosophila independently of canonical Wnt signaling.
the PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3
Title: The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3.
Pygo predisposes Drosophila T cell factor target genes for rapid Wingless-induced transcription, or it protects them against premature shut-down
Title: A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.
Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me).
Title: Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.
Pygopus promotes Wnt target gene transcription by recruiting the mediator complex through interactions with Med12 and Med13.
Title: Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based larval cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in delamination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing expansion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: pygopus

Names: CG11518-PA; gammy legs; pygo-PA; pygopous

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31575835..31580699 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143615.4 → NP_651872.1 pygopus [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651872.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V9W8

Related

FBpp0085167

Conserved Domains (1) summary

cd15637
Location:749 → 802

PHD_dPYGO; PHD finger found in Drosophila melanogaster protein pygopus (dPYGO) and similar proteins