Gcn2 Gcn2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gcn2provided by FlyBase
Official Full Name: Gcn2provided by FlyBase
Primary source: FLYBASE:FBgn0019990
Locus tag: Dmel_CG1609
See related: AllianceGenome:FB:FBgn0019990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1609; dGcn2; dGCN2; DGCN2; Dmel\CG1609; Gcn-2; GCN-2; gcn2; GCN2
Summary: Enables eukaryotic translation initiation factor 2alpha kinase activity. Involved in positive regulation of cell size and regulation of translational initiation by eIF2 alpha phosphorylation. Predicted to be located in cytosol. Is expressed in several structures, including embryonic/larval gut; gastrula embryo; larval ventral nerve cord; neurons; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 100C3-100C3; 3-102 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31395660..31402013)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27221382..27227735)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons.
Title: Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons.
Tissue-specific roles of GCN2 in aging and autosomal dominant retinitis pigmentosa.
Title: Tissue-specific roles of GCN2 in aging and autosomal dominant retinitis pigmentosa.
GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
Title: 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.
this study have characterised the first example of an invertebrate eIF2a phosphatase PPP1R15 (CG3825) and demonstrated that during development it primarily antagonises the function of GCN2.
Title: Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translational initiation in response to stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translational initiation	IC Inferred by Curator more info	PubMed
involved_in regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Gcn2

Names: CG1609-PA; CG1609-PB; CG1609-PC; GC nonderepressing 2 kinase; Gcn2-PA; Gcn2-PB; Gcn2-PC; general control nonderepressible 2; general control nonderepressing 2 kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31395660..31402013

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057882.4 → NP_477230.1 Gcn2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477230.1

Status: REVIEWED

UniProtKB/TrEMBL

O01712, O61651, Q9V9X8

Related

FBpp0085148

Conserved Domains (6) summary

smart00220
Location:523 → 893

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00591
Location:17 → 130

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

COG0124
Location:972 → 1412

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd14012
Location:259 → 474

PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cd14046
Location:516 → 896

STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cl00268
Location:972 → 1135

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
NM_001276213.1 → NP_001263142.1 Gcn2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263142.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHX7, O01712, O61651

Conserved Domains (6) summary

smart00220
Location:525 → 895

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00591
Location:17 → 130

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

COG0124
Location:974 → 1414

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd14012
Location:261 → 476

PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cd14046
Location:518 → 898

STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cl00268
Location:974 → 1137

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
NM_001276212.1 → NP_001263141.1 Gcn2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263141.1

Status: REVIEWED

UniProtKB/TrEMBL

O01712, O61651, Q9V9X8

Conserved Domains (6) summary

smart00220
Location:523 → 893

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00591
Location:17 → 130

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

COG0124
Location:972 → 1412

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd14012
Location:259 → 474

PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cd14046
Location:516 → 896

STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2

cl00268
Location:972 → 1135

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...