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acss2 acyl-CoA synthetase short chain family member 2 [ Danio rerio (zebrafish) ]

Gene ID: 436914, updated on 2-Nov-2024

Summary

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Official Symbol
acss2provided by ZNC
Official Full Name
acyl-CoA synthetase short chain family member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-388
See related
Ensembl:ENSDARG00000037781 AllianceGenome:ZFIN:ZDB-GENE-040718-388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa04c03; fj80b06; fj80h04; zgc:92200; wu:fa04c03; wu:fj80b06; wu:fj80h04
Summary
Predicted to enable acetate-CoA ligase activity. Predicted to be involved in acetyl-CoA biosynthetic process. Predicted to act upstream of or within acetyl-CoA biosynthetic process from acetate and lipid metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See acss2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (9230540..9288449)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (9295568..9353479)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438310 Neighboring gene ribosomal protein S21 Neighboring gene microtubule crosslinking factor 2 Neighboring gene oxysterol binding protein-like 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease. Tilghman JM, et al. N Engl J Med, 2019 Apr 11. PMID 30970187, Free PMC Article
  2. Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. Hu C, et al. Sci Total Environ, 2022 Jun 1. PMID 35151729
  3. Probiotic Modulation of Lipid Metabolism Disorders Caused by Perfluorobutanesulfonate Pollution in Zebrafish. Chen L, et al. Environ Sci Technol, 2020 Jun 16. PMID 32459962
  4. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetyl-CoA biosynthetic process from acetate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetyl-coenzyme A synthetase, cytoplasmic
NP_001315282.1
XP_005162010.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328353.1 → NP_001315282.1  acetyl-coenzyme A synthetase, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    CT027560, CU137717
    UniProtKB/TrEMBL
    A0A8M1P9T3, F1QAA7
    Related
    ENSDARP00000112054.3, ENSDART00000125122.4
    Conserved Domains (2) summary
    cd05966
    Location:34 → 682
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PRK00174
    Location:15 → 693
    PRK00174; acetyl-CoA synthetase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    9230540..9288449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161953.5 → XP_005162010.1  acetyl-coenzyme A synthetase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q6G5, A0A8M2B8S0
    Related
    ENSDARP00000146673.1, ENSDART00000187676.1
    Conserved Domains (2) summary
    cd05966
    Location:34 → 666
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
    PRK00174
    Location:15 → 677
    PRK00174; acetyl-CoA synthetase; Provisional

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395127.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    8339..47353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002641.1: Suppressed sequence

    Description
    NM_001002641.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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