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CG1544 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43689, updated on 2-Nov-2024

Summary

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Official Symbol
CG1544provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039827
Locus tag
Dmel_CG1544
See related
AllianceGenome:FB:FBgn0039827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1544
Summary
Predicted to enable 2-oxoadipate dehydrogenase activity. Predicted to be involved in generation of precursor metabolites and energy. Predicted to be located in mitochondrial membrane. Predicted to be part of oxoadipate dehydrogenase complex. Is expressed in adult brain; adult head; adult heart; and adult pars intercerebralis. Used to study Charcot-Marie-Tooth disease axonal type 2Q. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and transketolase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See CG1544 in Genome Data Viewer
Location:
100B5-100B5; 3-102 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31196916..31203722)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27022638..27029444)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase beta-subunit at 100B Neighboring gene slow termination of phototransduction Neighboring gene mesh Neighboring gene bottleneck Neighboring gene chaoptin Neighboring gene zwilch

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isoforms of the DHTKD1-Encoded 2-Oxoadipate Dehydrogenase, Identified in Animal Tissues, Are not Observed upon the Human DHTKD1 Expression in Bacterial or Yeast Systems. Boyko AI, et al. Biochemistry (Mosc), 2020 Aug. PMID 33045952
  2. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
  3. Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection. Guzman RM, et al. Genetics, 2021 Mar 31. PMID 33789347, Free PMC Article
  4. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
  5. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2-oxoadipate dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in generation of precursor metabolites and energy ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxoadipate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1544-PA
NP_651849.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31196916..31203722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143592.2 → NP_651849.1  uncharacterized protein Dmel_CG1544 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IGV6, Q8MT95, Q9VA02
    UniProtKB/TrEMBL
    T2FGC6
    Related
    FBpp0085117
    Conserved Domains (4) summary
    PRK09404
    Location:35 → 918
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:178 → 449
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:569 → 772
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16870
    Location:779 → 917
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VA02.2 Q9VA02

Gene LinkOut

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