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gstz1 glutathione S-transferase zeta 1 [ Danio rerio (zebrafish) ]

Gene ID: 436754, updated on 2-Nov-2024

Summary

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Official Symbol
gstz1provided by ZNC
Official Full Name
glutathione S-transferase zeta 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-184
See related
Ensembl:ENSDARG00000027984 AllianceGenome:ZFIN:ZDB-GENE-040718-184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92869; zgc:113898
Summary
Enables glutathione transferase activity. Predicted to be involved in L-phenylalanine catabolic process and glutathione metabolic process. Predicted to act upstream of or within tyrosine catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in brain; gill; liver; and pleuroperitoneal region. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gstz1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (45106424..45113806)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (44992659..45000041)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5a Neighboring gene aldehyde dehydrogenase 6 family, member A1 Neighboring gene zgc:163014 Neighboring gene transmembrane p24 trafficking protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway. Tierbach A, et al. Toxicol Sci, 2020 Aug 1. PMID 32428239
  2. Glutathione S-Transferase Protein Expression in Different Life Stages of Zebrafish (Danio rerio). Tierbach A, et al. Toxicol Sci, 2018 Apr 1. PMID 29361160, Free PMC Article
  3. Identification and characterization of the zebrafish glutathione S-transferase Pi-1. Abunnaja MS, et al. J Biochem Mol Toxicol, 2017 Oct. PMID 28621814
  4. Characterization of glutathione-S-transferases in zebrafish (Danio rerio). Glisic B, et al. Aquat Toxicol, 2015 Jan. PMID 25461745
  5. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Timme-Laragy AR, et al. Free Radic Biol Med, 2013 Dec. PMID 23770340, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC113898

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables maleylacetoacetate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables maleylacetoacetate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
maleylacetoacetate isomerase
NP_001002481.1
NP_001025442.2
NP_001306763.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002481.2 → NP_001002481.1  maleylacetoacetate isomerase isoform 2

    See identical proteins and their annotated locations for NP_001002481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    EH591704, FO704844
    UniProtKB/TrEMBL
    A0A8N7XJL6, B2GNJ6, Q6DGL3, X1WDK2
    Related
    ENSDARP00000128301.2, ENSDART00000155104.3
    Conserved Domains (3) summary
    cd03191
    Location:98 → 211
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:11 → 85
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:12 → 215
    maiA; maleylacetoacetate isomerase

  2. NM_001030271.2 → NP_001025442.2  maleylacetoacetate isomerase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    EH484549, FO704844
    UniProtKB/TrEMBL
    A0A8M1N7N9, X1WBU0
    Related
    ENSDARP00000127682.2, ENSDART00000156971.2
    Conserved Domains (3) summary
    cd03191
    Location:94 → 207
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cd03042
    Location:7 → 81
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    TIGR01262
    Location:8 → 211
    maiA; maleylacetoacetate isomerase

  3. NM_001319834.1 → NP_001306763.1  maleylacetoacetate isomerase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' most exon which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    EH436943, FO704844
    UniProtKB/TrEMBL
    A0A8M1P7I6, X1WD04
    Related
    ENSDARP00000128101.2, ENSDART00000157338.3
    Conserved Domains (2) summary
    cd03191
    Location:38 → 151
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cl00388
    Location:1 → 25
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    45106424..45113806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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