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brap BRCA1 associated protein [ Danio rerio (zebrafish) ]

Gene ID: 436739, updated on 17-Sep-2024

Summary

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Official Symbol
brapprovided by ZNC
Official Full Name
BRCA1 associated proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-168
See related
Ensembl:ENSDARG00000008560 AllianceGenome:ZFIN:ZDB-GENE-040718-168
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92894
Summary
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Is expressed in lens. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See brap in Genome Data Viewer
Location:
chromosome: 10
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3336772..3360212)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3336468..3358903)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene zgc:56235 Neighboring gene torsin family 4, member Aa Neighboring gene N-alpha-acetyltransferase 25, NatB auxiliary subunit Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BRCA1-associated protein
NP_001002466.1
XP_021334829.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002466.1 → NP_001002466.1  BRCA1-associated protein

    See identical proteins and their annotated locations for NP_001002466.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076350
    UniProtKB/TrEMBL
    Q6DGJ4
    Related
    ENSDARP00000103873.3, ENSDART00000109148.4
    Conserved Domains (5) summary
    cd00162
    Location:247 → 288
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12718
    Location:144 → 227
    RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
    pfam01496
    Location:411 → 499
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam02148
    Location:301 → 363
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl21478
    Location:460 → 554
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    3336772..3360212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479154.2 → XP_021334829.1  BRCA1-associated protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9QC17
    Conserved Domains (4) summary
    cd12718
    Location:143 → 226
    RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
    pfam02148
    Location:300 → 362
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cd16457
    Location:245 → 288
    RING-H2_BRAP2; RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
    cl25732
    Location:381 → 542
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394799.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    65422..73250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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