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zfyve19 zinc finger, FYVE domain containing 19 [ Danio rerio (zebrafish) ]

Gene ID: 436685, updated on 2-Nov-2024

Summary

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Official Symbol
zfyve19provided by ZNC
Official Full Name
zinc finger, FYVE domain containing 19provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-109
See related
Ensembl:ENSDARG00000003642 AllianceGenome:ZFIN:ZDB-GENE-040718-109
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92683
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission and mitotic cytokinesis checkpoint signaling. Predicted to be active in centrosome; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See zfyve19 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (2108902..2126657, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (1933703..1949844, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type 1 a Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14D Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Bb Neighboring gene p21 (RAC1) activated kinase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in abscission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
abscission/NoCut checkpoint regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002412.1 → NP_001002412.1  abscission/NoCut checkpoint regulator

    See identical proteins and their annotated locations for NP_001002412.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076167
    UniProtKB/TrEMBL
    Q6DH17
    Related
    ENSDARP00000002470.7, ENSDART00000013093.8
    Conserved Domains (2) summary
    PRK13890
    Location:101 → 177
    PRK13890; conjugal transfer protein TrbA; Provisional
    cd15749
    Location:4 → 54
    FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    2108902..2126657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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