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ift74 intraflagellar transport 74 [ Danio rerio (zebrafish) ]

Gene ID: 436658, updated on 12-Sep-2024

Summary

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Official Symbol
ift74provided by ZNC
Official Full Name
intraflagellar transport 74provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-81
See related
Ensembl:ENSDARG00000023495 AllianceGenome:ZFIN:ZDB-GENE-040718-81
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92052
Summary
Predicted to enable beta-tubulin binding activity. Acts upstream of or within gastrulation and pronephric proximal tubule development. Predicted to be part of intraciliary transport particle B. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22. Orthologous to human IFT74 (intraflagellar transport 74). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ift74 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (453821..478811)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (451010..472932)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495540 Neighboring gene THAP domain containing, apoptosis associated protein 1 Neighboring gene TEK tyrosine kinase, endothelial Neighboring gene uncharacterized LOC101883870

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome. Luo M, et al. Genet Med, 2021 Jun. PMID 33531668
  2. Tek (Tie2) is not required for cardiovascular development in zebrafish. Jiang Z, et al. Development, 2020 Oct 12. PMID 32928907
  3. Loss of Ift74 Leads to Slow Photoreceptor Degeneration and Ciliogenesis Defects in Zebrafish. Zhu P, et al. Int J Mol Sci, 2021 Aug 28. PMID 34502236, Free PMC Article
  4. Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. Xie H, et al. PLoS Biol, 2023 Mar. PMID 36862758, Free PMC Article
  5. Copy-Number Variation Contributes to the Mutational Load of Bardet-Biedl Syndrome. Lindstrand A, et al. Am J Hum Genet, 2016 Aug 4. PMID 27486776, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within opsin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric proximal tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of intraciliary transport particle B IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 74 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002385.1 → NP_001002385.2  intraflagellar transport protein 74 homolog

    Status: PROVISIONAL

    Source sequence(s)
    BC075870
    UniProtKB/TrEMBL
    A0A8M9PXA7, E7EZE3, Q6DHU7
    Related
    ENSDARP00000027867.10, ENSDART00000025183.10
    Conserved Domains (1) summary
    cl25732
    Location:89 → 430
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    453821..478811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476068.2 → XP_021331743.1  intraflagellar transport protein 74 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8M9PXA7, E7EZE3, Q6DHU7
    Conserved Domains (1) summary
    cl25732
    Location:89 → 430
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021476067.2 → XP_021331742.1  intraflagellar transport protein 74 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8M9PXA7, E7EZE3, Q6DHU7
    Conserved Domains (1) summary
    cl25732
    Location:89 → 430
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_068221138.1 → XP_068077239.1  intraflagellar transport protein 74 homolog isoform X2

  4. XM_021476066.2 → XP_021331741.1  intraflagellar transport protein 74 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q8D0, Q6DHU7
    Conserved Domains (1) summary
    cl25732
    Location:109 → 450
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
Heading Accession and Version

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