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kat5a K(lysine) acetyltransferase 5a [ Danio rerio (zebrafish) ]

Gene ID: 436638, updated on 2-Nov-2024

Summary

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Official Symbol
kat5aprovided by ZNC
Official Full Name
K(lysine) acetyltransferase 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-57
See related
Ensembl:ENSDARG00000004587 AllianceGenome:ZFIN:ZDB-GENE-040718-57
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92510
Summary
Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Acts upstream of or within primitive erythrocyte differentiation. Predicted to be located in chromatin. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in dorsal telencephalon. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See kat5a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23597140..23605946)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23093290..23102148)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene CWC15 spliceosome associated protein homolog Neighboring gene family with sequence similarity 76 member B Neighboring gene myotubularin related protein 2 Neighboring gene gap junction protein beta 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish. Zhou WH, et al. J Biol Chem, 2023 Oct. PMID 37660921, Free PMC Article
  2. The splicing factor DHX38 enables retinal development through safeguarding genome integrity. Sun K, et al. iScience, 2023 Nov 17. PMID 37867960, Free PMC Article
  3. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
  4. Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes. Fellous A, et al. Gene, 2019 Apr 5. PMID 30615915
  5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H4K16 acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within primitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone acetyltransferase KAT5a
NP_001002365.1
XP_005165196.1
XP_009299572.1
XP_009299573.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002365.1 → NP_001002365.1  histone acetyltransferase KAT5a

    See identical proteins and their annotated locations for NP_001002365.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076045
    UniProtKB/TrEMBL
    A0A8M1N097, Q6DHD0
    Related
    ENSDARP00000030282.5, ENSDART00000032909.5
    Conserved Domains (3) summary
    pfam01853
    Location:316 → 499
    MOZ_SAS; MOZ/SAS family
    pfam11717
    Location:8 → 65
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:247 → 535
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    23597140..23605946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005165139.5 → XP_005165196.1  histone acetyltransferase KAT5a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BCF7, B0R0X6
    Related
    ENSDARP00000113020.1, ENSDART00000142420.3
    Conserved Domains (3) summary
    pfam01853
    Location:295 → 478
    MOZ_SAS; MOZ/SAS family
    pfam11717
    Location:8 → 65
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:226 → 514
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  2. XM_009301297.4 → XP_009299572.1  histone acetyltransferase KAT5a isoform X2

    UniProtKB/TrEMBL
    A0A8M3AS91
    Conserved Domains (3) summary
    pfam01853
    Location:293 → 476
    MOZ_SAS; MOZ/SAS family
    pfam11717
    Location:8 → 65
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:224 → 512
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  3. XM_009301298.4 → XP_009299573.1  histone acetyltransferase KAT5a isoform X3

    UniProtKB/TrEMBL
    A0A8M3B2B3
    Conserved Domains (3) summary
    COG5027
    Location:11 → 484
    SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]
    pfam11717
    Location:8 → 65
    Tudor-knot; RNA binding activity-knot of a chromodomain
    cl17182
    Location:203 → 491
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
Heading Accession and Version

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