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thop1 thimet oligopeptidase 1 [ Danio rerio (zebrafish) ]

Gene ID: 436628, updated on 2-Nov-2024

Summary

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Official Symbol
thop1provided by ZNC
Official Full Name
thimet oligopeptidase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-47
See related
Ensembl:ENSDARG00000013776 AllianceGenome:ZFIN:ZDB-GENE-040718-47
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb74b01; zgc:92139; wu:fb74b01
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and proteolysis. Predicted to be active in mitochondrial intermembrane space. Is expressed in lens. Orthologous to human THOP1 (thimet oligopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See thop1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (7183099..7212097)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (7173225..7202258)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 7 Neighboring gene transmembrane protein 38A Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene zgc:113223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish lens proteome during development and aging. Greiling TM, et al. Mol Vis, 2009 Nov 13. PMID 19936306, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thimet oligopeptidase
NP_001002355.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002355.1 → NP_001002355.1  thimet oligopeptidase

    See identical proteins and their annotated locations for NP_001002355.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075901
    UniProtKB/TrEMBL
    A0A8M1N094, Q6DHR6
    Related
    ENSDARP00000046669.6, ENSDART00000046670.9
    Conserved Domains (2) summary
    cd06455
    Location:32 → 672
    M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
    COG0339
    Location:23 → 674
    Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    7183099..7212097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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