pls3 plastin 3 (T isoform) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pls3provided by ZNC
Official Full Name: plastin 3 (T isoform)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-10
See related: Ensembl:ENSDARG00000037655 AllianceGenome:ZFIN:ZDB-GENE-040718-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91903; wu:fc04g03
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within bone mineralization; embryonic cranial skeleton morphogenesis; and motor neuron axon guidance. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human PLS3 (plastin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (13453199..13525024)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (13147185..13219010)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

decreased PLS3 contributes to spinal muscular atrophy motor phenotypes
Title: Survival motor neuron affects plastin 3 protein levels leading to motor defects.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AI629195 (e-PCR)
- UniSTS:206126

fc32b04.x1 (e-PCR)
- UniSTS:193533

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric nephron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: plastin-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002326.1 → NP_001002326.1 plastin-3

See identical proteins and their annotated locations for NP_001002326.1

Status: PROVISIONAL

Source sequence(s)

BC076470

UniProtKB/Swiss-Prot

A0A0R4IB94, A0A8N7XJJ0, B2GNI5, Q6DG81

Related

ENSDARP00000054848.5, ENSDART00000054849.7

Conserved Domains (5) summary

smart00033
Location:519 → 620

CH; Calponin homology domain

COG5069
Location:4 → 620

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00014
Location:124 → 235

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:12 → 78

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:395 → 498

CH; Calponin homology (CH) domain