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Pka-C2 Protein kinase, cAMP-dependent, catalytic subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43644, updated on 18-Sep-2024

Summary

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Official Symbol
Pka-C2provided by FlyBase
Official Full Name
Protein kinase, cAMP-dependent, catalytic subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0000274
Locus tag
Dmel_CG12066
See related
AllianceGenome:FB:FBgn0000274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CdkB; CG12066; DC1; DC1a; Dmel\CG12066; PKA; PKA C2; PKA-C2; PKAC2
Summary
Predicted to enable cAMP-dependent protein kinase activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in peptidyl-serine phosphorylation and protein kinase A signaling. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha) and PRKACG (protein kinase cAMP-activated catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pka-C2 in Genome Data Viewer
Location:
100A2-100A2; 3-101 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30695537..30697138, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26521259..26522860, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Serpin 100A Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46115 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stress Odorant Sensory Response Dysfunction in Drosophila Fragile X Syndrome Mutants. Androschuk A, et al. Front Mol Neurosci, 2018. PMID 30135642, Free PMC Article
  2. Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling. Gonzales ED, et al. Hum Mol Genet, 2016 Mar 1. PMID 26604145, Free PMC Article
  3. Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3. Bettencourt da Cruz A, et al. J Neurosci, 2008 Oct 22. PMID 18945896, Free PMC Article
  4. Proteome-wide prediction of PKA phosphorylation sites in eukaryotic kingdom. Gao X, et al. Genomics, 2008 Dec. PMID 18817865
  5. Quantitative genetic analyses of complex behaviours in Drosophila. Anholt RR, et al. Nat Rev Genet, 2004 Nov. PMID 15520793

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase A regulatory subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein kinase, cAMP-dependent, catalytic subunit 2
Names
CG12066-PB
CG12066-PC
Pka-C2-PB
Pka-C2-PC
cAMP-dependent protein kinase 2
cAMP-dependent protein kinase type II
NP_524595.2
NP_733397.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30695537..30697138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079856.3 → NP_524595.2  protein kinase, cAMP-dependent, catalytic subunit 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524595.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHB5
    Conserved Domains (2) summary
    PTZ00263
    Location:42 → 353
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cl21453
    Location:43 → 333
    PKc_like; Protein Kinases, catalytic domain

  2. NM_170518.4 → NP_733397.2  protein kinase, cAMP-dependent, catalytic subunit 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733397.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16910, P16911, Q53XD8, Q8IMH7
    Related
    FBpp0085089
    Conserved Domains (1) summary
    cl21453
    Location:43 → 334
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0C4DHB5 A0A0C4DHB5
P16911.2 P16911

Gene LinkOut

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