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eIF2Balpha eukaryotic translation initiation factor 2B subunit alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43549, updated on 2-Nov-2024

Summary

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Official Symbol
eIF2Balphaprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 2B subunit alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0039726
Locus tag
Dmel_CG7883
See related
AllianceGenome:FB:FBgn0039726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7883; DeIF2Balpha; Dmel\CG7883; Eif2b; eIF2B-alpha
Summary
Enables enzyme regulator activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See eIF2Balpha in Genome Data Viewer
Location:
99C7-99C7; 3-99 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29934582..29935888, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25760304..25761610, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Mannosidase class I c Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13B Neighboring gene Tachykinin-like receptor at 99D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reducing the aneuploid cell burden - cell competition and the ribosome connection. Baker NE, et al. Dis Model Mech, 2022 Nov 1. PMID 36444717, Free PMC Article
  2. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
  3. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
  4. Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster. Gradilla AC, et al. Genetics, 2011 Nov. PMID 21900267, Free PMC Article
  5. Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Li X, et al. Sci Rep, 2016 Feb 25. PMID 26911346, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2B subunit alpha
Names
CG7883-PA
eIF2B-alpha
eIF2Balpha-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29934582..29935888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143495.3 → NP_651752.1  eukaryotic translation initiation factor 2B subunit alpha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GQ89, Q9VAD4
    Related
    FBpp0084874
    Conserved Domains (2) summary
    COG1184
    Location:31 → 305
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:30 → 294
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GQ89 Q9GQ89
Q9VAD4 Q9VAD4

Gene LinkOut

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