IntS11 Integrator 11 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: IntS11provided by FlyBase
Official Full Name: Integrator 11provided by FlyBase
Primary source: FLYBASE:FBgn0039691
Locus tag: Dmel_CG1972
See related: AllianceGenome:FB:FBgn0039691
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1972; Dmel\CG1972; dRC-68; Int11
Summary: Predicted to enable endoribonuclease activity. Involved in snRNA 3'-end processing. Predicted to be located in cytoplasm. Predicted to be part of integrator complex. Predicted to be active in nucleus. Is expressed in adult head; organism; and spermatozoon. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29745337..29747513)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25571059..25573235)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.
Title: Bi-allelic variants in INTS11 are associated with a complex neurological disorder.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in snRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed
involved_in snRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of integrator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain