Cap-D2 CAP-D2 condensin subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cap-D2provided by FlyBase
Official Full Name: CAP-D2 condensin subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0039680
Locus tag: Dmel_CG1911
See related: AllianceGenome:FB:FBgn0039680
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cap-D2; CAP-D2; CapD2; CG1911; dCap-D2; DmCAP-D2; Dmel\CG1911
Summary: Predicted to enable histone binding activity. Involved in mitotic chromosome condensation. Located in chromatin; cytoplasm; and nucleus. Part of condensin complex. Colocalizes with condensed chromosome, centromeric region. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; extended germ band embryo; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29675651..29680257)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25501373..25505979)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CAP-D2 is essential for chromosome arm and centromere resolution.
Title: Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IC Inferred by Curator more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

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