Ankrd13c ankyrin repeat domain 13c [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd13cprovided by MGI
Official Full Name: ankyrin repeat domain 13cprovided by MGI
Primary source: MGI:MGI:2139746
See related: Ensembl:ENSMUSG00000039988 AllianceGenome:MGI:2139746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in protein retention in ER lumen; regulation of anoikis; and regulation of signaling receptor activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with endoplasmic reticulum. Is expressed in cranial ganglion; dorsal root ganglion; foregut; liver; and submandibular gland primordium. Orthologous to human ANKRD13C (ankyrin repeat domain 13C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 24.1), kidney adult (RPKM 16.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3 81.59 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (157650886..157713671)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (157945420..158008034)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein retention in ER lumen	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein retention in ER lumen	IEA Inferred from Electronic Annotation more info
involved_in protein retention in ER lumen	ISO Inferred from Sequence Orthology more info
involved_in regulation of anoikis	IEA Inferred from Electronic Annotation more info
involved_in regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 13C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013806.2 → NP_001013828.1 ankyrin repeat domain-containing protein 13C isoform 1

See identical proteins and their annotated locations for NP_001013828.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC117211, AC145301, AI835245, AK135906, BC065088, BQ562764, CF736962

Consensus CDS

CCDS17933.1

UniProtKB/Swiss-Prot

B2RST2, Q3UX43, Q6P1G4

Related

ENSMUSP00000038662.9, ENSMUST00000040787.13

Conserved Domains (4) summary

cd00204
Location:115 → 199

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam11904
Location:259 → 532

GPCR_chapero_1; GPCR-chaperone

pfam13637
Location:144 → 197

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:115 → 141

ANK; ANK repeat [structural motif]
NM_001359909.1 → NP_001346838.1 ankyrin repeat domain-containing protein 13C isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5'UTR and initiates translation at a downstream start codon, compared to variant (1). The encoded isoform (2) has a shorter N-terminus, compared to isoform (1).

Source sequence(s)

AC117211, AC145301, AI835245

Conserved Domains (1) summary

pfam11904
Location:1 → 263

GPCR_chapero_1; GPCR-chaperone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

157650886..157713671

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163152.1 → XP_036019045.1 ankyrin repeat domain-containing protein 13C isoform X2

Conserved Domains (1) summary

pfam11904
Location:17 → 289

GPCR_chapero_1; GPCR-chaperone
XM_036163151.1 → XP_036019044.1 ankyrin repeat domain-containing protein 13C isoform X1

Conserved Domains (3) summary

sd00045
Location:115 → 141

ANK; ANK repeat [structural motif]

pfam11904
Location:259 → 302

GPCR_chapero_1; GPCR-chaperone

pfam12796
Location:117 → 199

Ank_2; Ankyrin repeats (3 copies)