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ALiX ALG-2 interacting protein X [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43330, updated on 18-Sep-2024

Summary

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Official Symbol
ALiXprovided by FlyBase
Official Full Name
ALG-2 interacting protein Xprovided by FlyBase
Primary source
FLYBASE:FBgn0086346
Locus tag
Dmel_CG12876
See related
AllianceGenome:FB:FBgn0086346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aip1; AIP1; alix; Alix; AliX; ALIX; CG12876; DAIP1; Dmel\CG12876; Snf7
Summary
Involved in several processes, including actin filament polymerization; germline stem cell asymmetric division; and positive regulation of JNK cascade. Located in several cellular components, including centrosome; intercellular bridge; and midbody. Is expressed in adult head. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ALiX in Genome Data Viewer
Location:
98B1-98B1; 3-94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27696466..27700110, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23522188..23525832, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 98AB Neighboring gene HSPB1 associated protein 1 Neighboring gene barentsz Neighboring gene Carnitine O-octanoyltransferase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The multifunctional polydnavirus TnBVANK1 protein: impact on host apoptotic pathway. Salvia R, et al. Sci Rep, 2017 Sep 18. PMID 28924205, Free PMC Article
  2. ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo. Eikenes ÅH, et al. PLoS Genet, 2015 Jan. PMID 25635693, Free PMC Article
  3. Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding. Lie-Jensen A, et al. Curr Biol, 2019 Oct 21. PMID 31607533
  4. Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics. Malerød L, et al. EMBO J, 2018 Jul 2. PMID 29858227, Free PMC Article
  5. POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. Tsuda M, et al. FEBS Lett, 2006 May 29. PMID 16698022

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding.
    Title: Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding.
  2. Our results demonstrate a novel evolutionarily conserved role of ALIX in providing robustness to the orientation of the mitotic spindle by promoting astral microtubule formation during asymmetric and symmetric cell division.
    Title: Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics.
  3. We conclude that ALIX and ESCRT-III coordinately control abscission in Drosophila fGSCs and that their complex formation is required for accurate abscission timing in GSCs in vivo.
    Title: ALIX and ESCRT-III coordinately control cytokinetic abscission during germline stem cell division in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exosomal secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ALG-2 interacting protein X
Names
ALG-2 interacting protein 1
ALiX-PA
CG12876-PA
apoptosis linked gene 2 interacting X

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27696466..27700110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143325.4 → NP_651582.1  ALG-2 interacting protein X [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651582.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB05
    Related
    FBpp0084610
    Conserved Domains (4) summary
    cd09235
    Location:362 → 698
    V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
    cd09240
    Location:2 → 347
    BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    pfam07777
    Location:733 → 822
    MFMR; G-box binding protein MFMR
    pfam13949
    Location:415 → 701
    ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB05 Q9VB05

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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