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Hsdl2 Hydroxysteroid dehydrogenase like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43325, updated on 2-Nov-2024

Summary

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Official Symbol
Hsdl2provided by FlyBase
Official Full Name
Hydroxysteroid dehydrogenase like 2provided by FlyBase
Primary source
FLYBASE:FBgn0039537
Locus tag
Dmel_CG5590
See related
AllianceGenome:FB:FBgn0039537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5590; Dmel\CG5590; HSDL2
Summary
Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Orthologous to human HSDL2 (hydroxysteroid dehydrogenase like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Hsdl2 in Genome Data Viewer
Location:
98B1-98B1; 3-94 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27677522..27679013)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23503244..23504735)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosin alkali light chain 1 Neighboring gene uncoordinated 80 Neighboring gene uncharacterized protein Neighboring gene Sex combs extra

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sex-dependent and sex-independent regulatory systems of size variation in natural populations. Okada H, et al. Mol Syst Biol, 2019 Nov. PMID 31777173, Free PMC Article
  2. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Yin J, et al. Nat Commun, 2021 Apr 23. PMID 33893307, Free PMC Article
  3. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article
  4. Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Hoffmann J, et al. Aging (Albany NY), 2013 Apr. PMID 23765091, Free PMC Article
  5. Characterization of the Drosophila lipid droplet subproteome. Beller M, et al. Mol Cell Proteomics, 2006 Jun. PMID 16543254

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables steroid dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
hydroxysteroid dehydrogenase like 2
Names
CG5590-PA
Hsdl2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27677522..27679013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143321.3 → NP_651578.1  hydroxysteroid dehydrogenase like 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651578.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB10
    Related
    FBpp0084585
    Conserved Domains (3) summary
    PRK08278
    Location:7 → 277
    PRK08278; short chain dehydrogenase; Provisional
    COG1028
    Location:5 → 245
    FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam02036
    Location:317 → 406
    SCP2; SCP-2 sterol transfer family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB10 Q9VB10

Gene LinkOut

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