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CG5639 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43314, updated on 2-Nov-2024

Summary

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Official Symbol
CG5639provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039527
Locus tag
Dmel_CG5639
See related
AllianceGenome:FB:FBgn0039527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT17816; Dmel\CG5639
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in cell-matrix adhesion. Predicted to be located in extracellular region. Predicted to be active in basement membrane and extracellular space. Is expressed in adult fat body. Orthologous to several human genes including WFDC10A (WAP four-disulfide core domain 10A); WFDC10B (WAP four-disulfide core domain 10B); and WFDC11 (WAP four-disulfide core domain 11). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG5639 in Genome Data Viewer
Location:
98A8-98A10; 3-94 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27586474..27596130, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23412196..23421852, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene widerborst Neighboring gene partner of inscuteable Neighboring gene distracted Neighboring gene tusp Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
  2. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
  3. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793
  4. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article
  5. Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. Egger B, et al. Development, 2002 Jul. PMID 12091301

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5639-PA
N-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27586474..27596130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143313.2 → NP_651570.1  uncharacterized protein Dmel_CG5639 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MST1, Q9VB21
    Related
    FBpp0084572
    Conserved Domains (5) summary
    cd00191
    Location:38 → 101
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00095
    Location:784 → 830
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    pfam02822
    Location:911 → 936
    Antistasin; Antistasin family
    pfam14625
    Location:180 → 225
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00150
    Location:1090 → 1184
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MST1 Q8MST1
Q9VB21 Q9VB21

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