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Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 [ Mus musculus (house mouse) ]

Gene ID: 432467, updated on 2-Nov-2024

Summary

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Official Symbol
Hnrnph3provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein H3provided by MGI
Primary source
MGI:MGI:1926462
See related
Ensembl:ENSMUSG00000020069 AllianceGenome:MGI:1926462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrph3
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in central nervous system and retina. Orthologous to human HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 51.4), CNS E14 (RPKM 36.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnph3 in Genome Data Viewer
Location:
10 B4; 10 32.52 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62850443..62859764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63014664..63023980, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62409633-62409742 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Cho KI, et al. Dis Model Mech, 2017 May 1. PMID 28100513, Free PMC Article
  2. Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development. Mahé D, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004512
  3. A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1. Korff A, et al. J Clin Invest, 2023 Jul 17. PMID 37463454, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. effects were accompanied by paracrine and autocrine neuroglial deregulation of hnRNPH3 proteostasis in sciatic nerve and motoneurons, respectively, and post-transcriptional downregulation of metalloproteinase 28 in the sciatic nerve
    Title: Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein H3
Names
hnRNP 2H9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079824.1 → NP_001073293.1  heterogeneous nuclear ribonucleoprotein H3 isoform 1

    See identical proteins and their annotated locations for NP_001073293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC113107, AI666703, BQ443117, BU946493, BX514270
    Consensus CDS
    CCDS48583.1
    UniProtKB/TrEMBL
    D3Z3N4
    Related
    ENSMUSP00000020263.8, ENSMUST00000020263.14
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  2. NM_001347457.1 → NP_001334386.1  heterogeneous nuclear ribonucleoprotein H3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC113107, AI666703, BQ443117, BX514270
    Consensus CDS
    CCDS83704.1
    UniProtKB/TrEMBL
    D3YWT1
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  3. NM_001359260.1 → NP_001346189.1  heterogeneous nuclear ribonucleoprotein H3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AA444345, AC113107, AI666703, BQ443117
    Consensus CDS
    CCDS48583.1
    UniProtKB/TrEMBL
    D3Z3N4
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  4. NM_001359261.1 → NP_001346190.1  heterogeneous nuclear ribonucleoprotein H3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113107, AI666703, BM948718, BQ443117, BX514270
    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62850443..62859764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513839.5 → XP_006513902.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

    See identical proteins and their annotated locations for XP_006513902.1

    UniProtKB/TrEMBL
    D3YWT1
    Related
    ENSMUSP00000112424.2, ENSMUST00000118898.8
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  2. XM_030245163.1 → XP_030101023.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_030245166.1 → XP_030101026.1  heterogeneous nuclear ribonucleoprotein H3 isoform X4

    Conserved Domains (1) summary
    cl17169
    Location:44 → 106
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_006513837.4 → XP_006513900.1  heterogeneous nuclear ribonucleoprotein H3 isoform X1

    See identical proteins and their annotated locations for XP_006513900.1

    UniProtKB/TrEMBL
    D3Z3N4
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  5. XM_030245159.2 → XP_030101019.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

    UniProtKB/TrEMBL
    D3YWT1
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  6. XM_030245164.1 → XP_030101024.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_030245168.2 → XP_030101028.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_030245167.2 → XP_030101027.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_030245170.1 → XP_030101030.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_030245165.1 → XP_030101025.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_030245158.1 → XP_030101018.1  heterogeneous nuclear ribonucleoprotein H3 isoform X1

    UniProtKB/TrEMBL
    D3Z3N4
    Conserved Domains (2) summary
    cd12735
    Location:195 → 269
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  12. XM_030245160.1 → XP_030101020.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

    UniProtKB/TrEMBL
    D3YWT1
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  13. XM_030245161.1 → XP_030101021.1  heterogeneous nuclear ribonucleoprotein H3 isoform X2

    UniProtKB/TrEMBL
    D3YWT1
    Conserved Domains (2) summary
    cd12735
    Location:180 → 254
    RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    cd12732
    Location:1 → 93
    RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

  14. XM_030245162.1 → XP_030101022.1  heterogeneous nuclear ribonucleoprotein H3 isoform X3

    Conserved Domains (1) summary
    cl17169
    Location:64 → 138
    RRM_SF; RNA recognition motif (RRM) superfamily

  15. XM_030245169.1 → XP_030101029.1  heterogeneous nuclear ribonucleoprotein H3 isoform X5

    Conserved Domains (1) summary
    cl17169
    Location:26 → 100
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
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