Slco4c1 solute carrier organic anion transporter family, member 4C1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco4c1provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 4C1provided by RGD
Primary source: RGD:1303048
See related: EnsemblRapid:ENSRNOG00000022711 AllianceGenome:RGD:1303048
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oatp-H; Oatp-M1; Oatp4c1; Slc21A20
Summary: Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in organic anion transport. Located in basolateral plasma membrane. Biomarker of kidney failure. Orthologous to human SLCO4C1 (solute carrier organic anion transporter family member 4C1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Lung (RPKM 141.4), Kidney (RPKM 109.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (104624802..104676462, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (97177497..97229161, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (104301935..104350262, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data definitively demonstrate the subcellular localization and histological location of Oatp4c1.
Title: Localization and functional characterization of the rat Oatp4c1 transporter in an in vitro cell system and rat tissues.
isolation, cloning, and activity in the transport pathway of digoxin in the kidney (Oatp4c1)
Title: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables organic anion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic anion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 4C1

Names: Organic anion transporter member 4C1; organic anion transporting polypeptide 4C1; solute carrier family 21 member 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002024.2 → NP_001002024.2 solute carrier organic anion transporter family member 4C1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q71MB6

UniProtKB/TrEMBL

F1LRH8

Related

ENSRNOP00000037089.4, ENSRNOT00000033958.6

Conserved Domains (1) summary

cd17463
Location:100 → 604

MFS_SLCO4C_OATP4C; Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters