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IntS12 Integrator 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43227, updated on 2-Nov-2024

Summary

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Official Symbol
IntS12provided by FlyBase
Official Full Name
Integrator 12provided by FlyBase
Primary source
FLYBASE:FBgn0039459
Locus tag
Dmel_CG5491
See related
AllianceGenome:FB:FBgn0039459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5491; Dmel\CG5491; Int12
Summary
Involved in snRNA 3'-end processing. Located in cytosol and nucleus. Is expressed in organism. Orthologous to human INTS12 (integrator complex subunit 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See IntS12 in Genome Data Viewer
Location:
97D3-97D3; 3-92 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26863376..26864559)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22689098..22690281)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lysosomal enzyme receptor protein Neighboring gene long non-coding RNA:CR46073 Neighboring gene mir-1012 stem loop Neighboring gene ballchen Neighboring gene Histone H2A variant

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Elrod ND, et al. Mol Cell, 2019 Dec 5. PMID 31809743, Free PMC Article
  2. Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders. MacPherson RA, et al. Genetics, 2023 Aug 9. PMID 37036413, Free PMC Article
  3. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
  4. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
  5. Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function. Lin MH, et al. Mol Cell, 2024 Aug 8. PMID 39032490,

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex
    Title: Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator 12
Names
CG5491-PA
IntS12-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26863376..26864559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143250.3 → NP_651507.1  integrator 12 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651507.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VBB3
    Related
    FBpp0084433
    Conserved Domains (1) summary
    cd15501
    Location:130 → 182
    PHD_Int12; PHD finger found in integrator complex subunit 12 (Int12) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBB3.1 Q9VBB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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