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hdgfl2.L HDGF like 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 432209, updated on 4-Nov-2024

Summary

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Official Symbol
hdgfl2.L
Official Full Name
HDGF like 2 L homeolog
Primary source
Xenbase:XB-GENE-6255752
Locus tag
XELAEV_18006106mg
See related
EnsemblRapid:ENSXLAG00005016152 AllianceGenome:Xenbase:XB-GENE-6255752
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hrp2; hdgf2; hdgfl2; hdgfrp2; hdgfrp2.L
Summary
Predicted to enable H3K27me3 modified histone binding activity and H3K9me3 modified histone binding activity. Predicted to act upstream of or within positive regulation of double-strand break repair via homologous recombination. Predicted to be located in cytoplasm and nucleus. Orthologous to human HDGFL2 (HDGF like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hdgfl2.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (101455491..101481388, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (89807286..89833183, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121393224 Neighboring gene leucine-rich alpha-2-glycoprotein 1 L homeolog Neighboring gene perilipin 3 L homeolog Neighboring gene UBX domain protein 6 L homeolog Neighboring gene chromatin assembly factor 1 subunit A L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC80064, MGC132089

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables H3K27me3 modified histone binding IEA
Inferred from Electronic Annotation
more info
  
enables H3K9me3 modified histone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
hepatoma-derived growth factor-related protein 2
Names
HRP-2
hepatoma-derived growth factor-related protein 2 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091663.1 → NP_001085132.1  hepatoma-derived growth factor-related protein 2

    See identical proteins and their annotated locations for NP_001085132.1

    Status: PROVISIONAL

    Source sequence(s)
    BC108775
    UniProtKB/Swiss-Prot
    Q32N87, Q6INX7
    UniProtKB/TrEMBL
    A0A974DY93
    Related
    ENSXLAP00005047527.1, ENSXLAT00005048637.1
    Conserved Domains (2) summary
    cd05834
    Location:3 → 87
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    pfam11467
    Location:464 → 562
    LEDGF; Lens epithelium-derived growth factor (LEDGF)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    101455491..101481388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32N87.1 GenPept UniProtKB/Swiss-Prot:Q32N87

Gene LinkOut

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Molecular Biology Databases
Research Materials