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c7.S complement C7 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 432189, updated on 4-Nov-2024

Summary

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Official Symbol
c7.S
Official Full Name
complement C7 S homeolog
Primary source
Xenbase:XB-GENE-5894929
Locus tag
XELAEV_18010997mg
See related
EnsemblRapid:ENSXLAG00005001606 AllianceGenome:Xenbase:XB-GENE-5894929
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
c7
Summary
Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and killing of cells of another organism. Predicted to be located in extracellular space. Predicted to be part of membrane attack complex. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See c7.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (184511184..184544294, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (164672747..164705859, complement)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene 3-oxoacid CoA-transferase 1 S homeolog Neighboring gene PI-PLC X domain-containing protein 3 Neighboring gene uncharacterized LOC108707304 Neighboring gene small nucleolar RNA SNORD72 Neighboring gene small nucleolar RNA SNORD72 Neighboring gene ribosomal protein L37 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82368

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within complement activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement C7 S homeolog
Names
complement component 7 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091647.1 → NP_001085116.1  complement C7 S homeolog precursor

    See identical proteins and their annotated locations for NP_001085116.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072259
    UniProtKB/TrEMBL
    A0A974I2C0, Q6INM0
    Related
    ENSXLAP00005004799.1, ENSXLAT00005004896.1
    Conserved Domains (5) summary
    cd00033
    Location:559 → 615
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00057
    Location:692 → 754
    FIMAC; factor I membrane attack complex
    smart00209
    Location:28 → 78
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:85 → 117
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:219 → 434
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    184511184..184544294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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